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Nb2C MXene-Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects

Junhui Yin Shanshan Pan Xiang Guo Youshui Gao Daoyu Zhu Qianhao Yang Junjie Gao Changqing Zhang Yu Chen

纳微快报（英文）2021，Vol.13Issue(2)：162-179,18.

Nb2C MXene-Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects

Nb2C MXene?Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects

Junhui Yin ¹Shanshan Pan ²Xiang Guo ³Youshui Gao ⁴Daoyu Zhu ⁵Qianhao Yang ²Junjie Gao ²Changqing Zhang ²Yu Chen²

作者信息

1. Institute of Microsurgery On Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, People's Republic of China
2. Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, People's Republic of China
3. School of Life Sciences, Shanghai University, Shanghai 200444, People's Republic of China
4. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China
5. Department of Orthopedics, The Second Affiliated Hospital, The Navy Medical University, Shanghai 200003, People's Republic of China
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摘要

Abstract

Early surgical resection and chemotherapy of bone cancer are commonly used in the treatment of bone tumor, but it is still highly challenging to prevent recurrence and fill the bone defect caused by the resection site. In this work, we report a rational inte-gration of photonic-responsive two-dimensional (2D) ultrathin niobium carbide (Nb2C) MXene nanosheets (NSs) into the 3D-printed bone-mimetic scaffolds (NBGS) for osteosar-coma treatment. The integrated 2D Nb2C-MXene NSs feature specific photonic response in the second near-infrared (NIR-II) biowindow with high tissue-penetrating depth, making it highly efficient in killing bone cancer cells. Importantly, Nb-based species released by the biodegradation of Nb2C MXene can obviously promote the neogenesis and migration of blood vessels in the defect site, which can transport more oxygen, vitamins and energy around the bone defect for the reparative process, and gather more immune cells around the defect site to accelerate the degradation of NBGS. The degradation of NBGS provides sufficient space for the bone remodeling. Besides, calcium and phosphate released during the degradation of the scaffold can promote the mineralization of new bone tissue. The intrinsic multifunctionality of killing bone tumor cell and promoting angiogenesis and bone regeneration makes the engineered Nb2C MXene-integrated composite scaffolds a distinctive implanting biomaterial on the efficient treatment of bone tumor.

关键词

Nb2C MXene/3D printing/Phototherapy/Osteosarcoma/Vascularization

Key words

Nb2C MXene/3D printing/Phototherapy/Osteosarcoma/Vascularization

引用本文复制引用

Junhui Yin,Shanshan Pan,Xiang Guo,Youshui Gao,Daoyu Zhu,Qianhao Yang,Junjie Gao,Changqing Zhang,Yu Chen..Nb2C MXene-Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects[J].纳微快报（英文）,2021,13(2):162-179,18.

基金项目

We greatly acknowledge the financial sup-port from the National Key R&D Program of China (Grant No. 2016YFA0203700), the National Natural Science Foundation of China (Grant Nos. 51872185, 51722211, 51672303, 81672131, 81672143, 82072417 and 81802247), the Program of Shang-hai Academic Research Leader (Grant No. 18XD1404300), the National Key Research and Development Project of China (Grant No. 2018YFC1106303) and the Science and Technology Commis-sion of Shanghai Municipality (Grant No. 17060502400). （Grant No. 2016YFA0203700）

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