纳微快报（英文）2021，Vol.13Issue(2)：279-304,26.
Bacteria-Mediated Synergistic Cancer Therapy: Small Microbiome Has a Big Hope
Bacteria?Mediated Synergistic Cancer Therapy: Small Microbiome Has a Big Hope
摘要
Abstract
The use of bacteria to specifically migrate to cancerous tissue and elicit an antitumor immune response provides a promising platform against cancer with significantly high potency. With dozens of clinical trials underway, some researchers hold the following views: "humans are nearing the first commercial live bacteria therapeutic." However, the facultative anaerobe Salmonella typhimurium VNP20009, which is particularly safe and shows anticancer effects in preclinical studies, had failed in a phase I clinical trial due to low tumor regression and undesired dose-dependent side effects. This is almost certain to dis-appoint people's inflated expectations, but it is noted that recent state-of-the-art research has turned attention to bacteria-mediated synergisticcancer therapy (BMSCT). In this review, the foundation of bacteria-mediated bio-therapy is outlined. Then, we summarize the potential benefits and challenges of bacterial bio-therapy in combination with different traditional anticancer therapeutic modalities (chemotherapy, photothermal therapy, reactive oxygen and nitrogen species therapy, immunotherapy, or prodrug-activating therapy) in the past 5 years. Next, we discuss multiple administration routes of BMSCT, highlighting potentiated antitumor responses and avoidance of potential side effects. Finally, we envision the opportunities and challenges for BMSCT development, with the purpose of inspiring medicinal scientists to widely utilize the microbiome approach in patient populations.关键词
Bacteria-mediated synergistic cancer therapy/Multiple administration routes/Antitumor responses/Potential side effects/Microbiome approachKey words
Bacteria-mediated synergistic cancer therapy/Multiple administration routes/Antitumor responses/Potential side effects/Microbiome approach引用本文复制引用
Xinyu Lou,Zhichao Chen,Zhonggui He,Mengchi Sun,Jin Sun..Bacteria-Mediated Synergistic Cancer Therapy: Small Microbiome Has a Big Hope[J].纳微快报（英文）,2021,13(2):279-304,26.基金项目
This work was supported by Supported by National Natural Science Foundation of China, No. 81773656, Liaoning Revitalization Talents Program, No. XLYC1808017, and Shenyang Youth Science and Technology Innovation Talents Program, No. RC190454. （）
