LncRNA BCAR4调控JAK2/STAT3信号通路对食管癌细胞侵袭、迁移、炎症和凋亡的影响OACSTPCD
LncRNA BCAR4 affects the migration,invasion,inflammation and apoptosis of esophageal cancer cells through regulation of JAK2/STAT3 pathway
目的:探讨长链非编码RNA(lncRNA)乳腺癌抗雌激素抵抗4(BCAR4)介导JAK激酶2/信号转导与转录因子3(JAK2/STAT3)信号通路对食管癌细胞迁移、侵袭、凋亡和炎症因子分泌的影响.方法:采用实时荧光定量PCR(qRT-PCR)法检测BCAR4在食管癌细胞中的表达.在食管癌EC9706细胞中转染BCAR4小干扰RNA(si-BCAR4),Transwell和流式细胞术分别检测细胞迁移、侵袭和凋亡,Westernblot法检测白细胞介…查看全部>>
Objective:To investigate the effect of long-chain non-coding RNA(lncRNA)breast cancer anti-estrogen resis-tance 4(BCAR4)-mediated JAK kinase 2/signal transduction and transcription factor 3(JAK2/STAT3)signal pathway on mi-gration,invasion,apoptosis and inflammation of esophageal cancer cells.Methods:The expression of BCAR4 in esophageal cancer cells was detected by qPCR.BCAR4 small interference RNA(si-BCAR4)was transfected in esophageal cancer EC9706 cells.C…查看全部>>
彭文;范长玲;张浩
海南省儋州市人民医院胸心肿瘤外科,儋州 571799海南省儋州市人民医院病理科,儋州 571799海南省儋州市人民医院病理科,儋州 571799
医药卫生
BCAR4JAK2/STAT3信号通路食管癌迁移侵袭凋亡炎症
BCAR4JAK2/STAT3 signal pathwayesophageal cancermigrationinvasionapoptosisinflammation
《广西医科大学学报》 2020 (12)
2095-2102,8
This study was funded by Health Commission of Hainan Province(No.1605320273A-2001).
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