物理化学学报2020，Vol.36Issue(12)：65-75,11.DOI:10.3866/PKU.WHXB202005038
电刺激治疗神经系统损伤疾病:研究进展与展望
Electrical Stimulation for Nervous System Injury:Research Progress and Prospects
摘要
Abstract
Nervous system injury can disrupt communications between neurons,leading to loss of basic nerve functions and even paralysis.The clinical prognosis of nervous system injury is usually poor.This adversely affects the physical and mental health of patients and their families,and causes serious economic losses to the society.Due to slow and incomplete healing,the regenerative capacity of the nervous system is limited.Despite development of various biomedical treatment options such as,stem cell transplantation,neurotrophic factors and scaffold application,it is still very difficult to achieve adequate therapeutic effects that can benefit clinical practice.It is worth noting that nervous system components are closely related to electric fields(EFs),and a fundamental property of neurons is plasticity in response to endogenous and exogenous electrical stimulations.Electrical stimulation has been applied by researchers to induce nerve repair.This review summarizes the progress in research on EFs on neurons and applications of EFs in the treatment of peripheral nerve system and central nerve system injuries,focusing on the methods and effects of electrical stimulation.Research using direct,alternating,and pulsed EFs,with various parameters,has all demonstrated its positive effects on nerve healing and motor function recovery.Research on nanogenerators(NGs),a novel electrical stimulation technology that can convert mechanical energy into electrical energy,has achieved great progress in recent years.In biomedicine,NGs can collect the mechanical energy of human motion and convert it into electrical stimulations without requiring an external power supply,which can lead to significant innovations in electrical stimulation therapy.This review also discusses the recent applications of NGs in the treatment of nervous system diseases.NGs can be used to fabricate miniature,ultra-thin,flexible,and biodegradable healthcare devices according to different application scenarios such as in vivo or in vitro.NGs have enabled specific applications in deep brain stimulation,peripheral nerve stimulation,muscle stimulation,and sensory substitution to restore nervous system function.In order to apply electrical stimulation therapy in the clinical setting and improve the quality of life of patients with neurological injuries,further research into stimulation devices and their settings and parameters is highly desirable.关键词
电刺激/神经系统损伤/神经电极/功能修复/纳米发电机Key words
Electrical stimulation/Nervous system injury/Neural electrode/Functional recovery/Nanogenerator分类
化学化工引用本文复制引用
单义珠,封红青,李舟..电刺激治疗神经系统损伤疾病:研究进展与展望[J].物理化学学报,2020,36(12):65-75,11.基金项目
The project was supported by the National Natural Science Foundation of China(81971770,61875015),the University of Chinese Academy of Sciences,and the National Youth Talent Support Program.国家自然科学基金(81971770,61875015),中国科学院大学,国家万人计划"青年拔尖"项目资助 （81971770,61875015）
