南方医科大学学报2021，Vol.41Issue(2)：157-163,7.DOI:10.12122/j.issn.1673-4254.2021.02.01
武汉市COVID-19住院患者急性肾损伤的发生:287例单中心回顾性分析
Acute kidney injury in patients hospitalized with COVID-19 in Wuhan, China:a single-center retrospective observational study
摘要
Abstract
Objective To assess the predictors and outcomes of acute kidney injury (AKI) among patients with coronavirus disease 2019 (COVID-19). Methods This retrospective observational study was conducted among patients with a confirmed diagnosis of COVID-19 admitted to Hankou Hospital between January, 5 and March 8, 2020. We evaluated the association of AKI with the demographic and biochemical parameters and clinical outcomes of the patients using univariate regression analysis. Results A total of 287 COVID-19 patients, including 55 with AKI and 232 without AKI, were included in the analysis. Compared with the patients without AKI, the patients with AKI were older, predominantly male, and were more likely to have hypoxia and pre-existing hypertension and cerebrovascular diseases. The patients with AKI also had higher levels of white blood cells, D-dimer, aspartate aminotransferase, total bilirubin, creatine kinase, lactate dehydrogenase, procalcitonin, C-reactive protein, a higher prevalence of hyperkalemia, lower lymphocyte counts, and higher chest computed tomographic scores. The incidence of stage 1 AKI was 14.3％and that of stage 2 or 3 AKI was 4.9％. The patients with AKI had much higher mortality rate than those without AKI. Conclusions AKI is an important complication of COVID-19. An older age, a male gender, multiple pre-existing comorbidities, lymphopenia, increased infection indicators, elevated D-dimer, and impaired heart and liver functions are all potential risk factors of AKI. COVID-19 patients with AKI that progresses into stages 2 or 3 AKI have a high mortality rate. Prevention of AKI and monitoring kidney function is critical in the care of COVID-19 patients.关键词
COVID-19/急性肾损伤/肾功能Key words
coronavirus disease 2019/acute kidney injury/kidney function引用本文复制引用
肖冠华,陈仲清,蔡淑敏,胡鸿彬,吴凤,沙桐,曾振华,黄巧冰,李海军,韩家发,宋文鸿..武汉市COVID-19住院患者急性肾损伤的发生:287例单中心回顾性分析[J].南方医科大学学报,2021,41(2):157-163,7.基金项目
Supported by National Natural Science Foundation of China (81871604), Natural Science Foundation of Guangdong Province (2020A151501361, 2017A030313590). 基金项目:国家自然科学基金(81871604) （81871604）
广东省自然科学基金(2020A151501361,2017A030313590) （2020A151501361,2017A030313590）
