纳微快报（英文）2021，Vol.13Issue(4)：43-57,15.
Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy
Gold Nanostars?AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image?Guided Photodynamic Therapy
摘要
Abstract
Dual-functional aggregation-induced photosensi-tizers (AIE-PSs) with singlet oxy-gen generation (SOG) ability and bright fluorescence in aggregated state have received much attention in image-guided photodynamic therapy (PDT). However, design-ing an AIE-PS with both high SOG and intense fluorescence via molecular design is still chal-lenging. In this work, we report a new nanohybrid consisting of gold nanostar (AuNS) and AIE-PS dots with enhanced fluorescence and photosensitization for theranostic applications. The spectral overlap between the extinction of AuNS and fluorescence emission of AIE-PS dots (665 nm) is carefully selected using five different AuNSs with distinct localized surface plasmon (LSPR) peaks. Results show that all the AuNSs can enhance the 1O2 production of AIE-PS dots, among which the AuNS with LSPR peak at 585 nm exhibited the highest 1O2 enhancement factor of 15-fold with increased fluorescence brightness. To the best of our knowledge, this is the highest enhancement factor reported for the metal- enhanced singlet oxygen generation systems. The Au585@AIE-PS nanodots were applied for simultaneous fluorescence imaging and pho- todynamic ablation of HeLa cancer cells with strongly enhanced PDT efficiency in vitro. This study provides a better understanding of the metal-enhanced AIE-PS nanohybrid systems, opening up new avenue towards advanced image-guided PDT with greatly improved efficacy.关键词
Plasmon enhancement/Photosensitizer/Aggregation-induced emission/Fluorescence imaging/TheranosticsKey words
Plasmon enhancement/Photosensitizer/Aggregation-induced emission/Fluorescence imaging/Theranostics引用本文复制引用
Mohammad Tavakkoli Yaraki,Min Wu,Eshu Middha,Wenbo Wu,Soroosh Daqiqeh Rezaei,Bin Liu,Yen Nee Tan..Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy[J].纳微快报（英文）,2021,13(4):43-57,15.基金项目
M.T.Y. and S.D.R. would like to thank the Agency of Science, Technology and Research (A*STAR), Singa-pore for the SINGA scholarships. This work was supported by the Institute of Materials Research and Engineering under Biomimetic and Biomedical Materials program (IMRE/00-1P1400), Newcastle University (RSA/CCEAMD5010) and National University of Sin-gapore (R279-000- 482-133). The funding from NRF Investigator-ship (R279-000-444-281) is also appreciated. （A*STAR）
