分析测试学报2021，Vol.40Issue(2)：171-183,13.DOI:10.3969/j.issn.1004-4957.2021.02.002
样品预处理与实时直接分析质谱的联用技术及应用
Combination of Sample Pretreatment and Direct Analysis in Real-time Mass Spectrometry:Technologies and Applications
摘要
Abstract
In recent years,the rapid development of sample pretreatment techniques interfaced with direct analysis in real-time mass spectrometry(DART-MS)has allowed for the direct analysis on target analytes in complex biological,environmental,forensic and food environments,as well as individual small organisms and single-cell samples.How-ever,difficulties in detecting the internal analytes in solid matrices and the poor detection performance of trace analytes have become key problems restricting the further development of DART-MS.To solve these problems,several at-tempts have been made in different research fields to combine sample pretreatment methods with MS.The combinations of sample pretreatment techniques,such as solid-phase extraction(SPE),dispersive solid-phase extraction(DSPE),stir-bar sorptive extraction(SBSE),solid-phase microextraction(SPME),mechanochemical extraction(MCE)and mi-crowave-assisted extraction(MAE)with DART-MS are summarized in this review.The improvements that these com-bined methods may offer are detailed,and the future development trends are also proposed.It is hoped that this review will provide a reference or a basis for the future advancement of new sample treatment techniques in combination with DART-MS.关键词
原位电离质谱/实时直接分析质谱(DART-MS)/样品预处理/综述Key words
ambient ionization mass spectrometry/direct analysis in real-time mass spectrometry(DART-MS)/sample pretreatment technique/review分类
化学化工引用本文复制引用
刘敏,曹丹,李圣男,毕文韬..样品预处理与实时直接分析质谱的联用技术及应用[J].分析测试学报,2021,40(2):171-183,13.基金项目
the National Natural Science Foundation of China(21507062,21475061) （21507062,21475061）
the Natural Science of Foundation of Hebei Prov-ince(B2018201270) （B2018201270）
the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Minis-try([2015]1098) （[2015]1098）
Program of Natural Science Research of Jiangsu Higher Education Institutions of China(16KJB150022) （16KJB150022）
the Priority Academic Program Development of Jiangsu Higher Education Institutions,Jiangsu Collaborative Innovation Center of Biomedical Functional Materials （）
