数字中医药（英文）2021，Vol.4Issue(1)：9-18,10.DOI:10.1016/j.dcmed.2021.03.002
基于外排转运体的中药解毒作用
Detoxification of toxic herbs in TCM prescription based on modulation of efflux transporters
摘要
Abstract
Traditional Chinese medicines (TCMs) have been used to prevent and treat various diseases for thousands of years. Promoting efficacy and reducing toxicity by the compatibility theory of TCMs has attracted increasing attention, especially for the toxicity of herbs. Studies have pointed out the interactions between the active compounds of herbs and transporters in the detoxification process of toxic compounds. Here, we summarize data on five toxic herbs commonly used in TCMs and their related efflux transporters to reduce toxicity to offer a scientific rationale for the compatibility principle of TCMs and provide guidance for the rational clinical use of TCMs.关键词
毒性药物/外排转运体/解毒作用/中药配伍理论/P-糖蛋白Key words
Toxic herbs/Efflux transporters/Detoxification/TCMs compatibility principles/P-glycoprotein (P-gp)引用本文复制引用
钱李雲鶴,赫宇霏,张玫,谢莹..基于外排转运体的中药解毒作用[J].数字中医药（英文）,2021,4(1):9-18,10.基金项目
We thank for the funding support from the Science and Technology Development Fund, Macau SAR (No. 0040/2020/A and No. 0075/2019/AMJ). （No. 0040/2020/A and No. 0075/2019/AMJ）
