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Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion

Barbara Bojko German Gómez-Ríos Marcos Tascon Krzysztof Goryński Marcelo Cypel Janusz Pawliszyn Nikita Looby Mariola Olkowicz Anna Roszkowska Bogumiła Kupcewicz Pedro Reck dos Santos Khaled Ramadan Shaf Keshavjee Thomas K.Waddell

药物分析学报（英文）2021，Vol.11Issue(1)：37-47,11.

Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion

Barbara Bojko ¹German Gómez-Ríos ²Marcos Tascon ¹Krzysztof Goryński ¹Marcelo Cypel ¹Janusz Pawliszyn ²Nikita Looby ³Mariola Olkowicz ¹Anna Roszkowska ¹Bogumiła Kupcewicz ¹Pedro Reck dos Santos ⁴Khaled Ramadan ¹Shaf Keshavjee ⁵Thomas K.Waddell⁶

作者信息

1. Department of Chemistry,University of Waterloo,Waterloo,ON M1B 6G3,Canada
2. Department of Pharmacodynamics and Molecular Pharmacology,Faculty of Pharmacy,Collegium Medicum in Bydgoszcz,Nicolaus Copernicus University in Torun,85-089,Bydgoszcz,Poland
3. University Health Network-TGH,Toronto,ON M5G 2C4,Canada
4. Jagiellonian Centre for Experimental Therapeutics(JCET),Jagiellonian University,30-348 Krakow,Poland
5. Department of Pharmaceutical Chemistry,Medical University of Gdansk,80-416,Gdansk,Poland
6. Department of Inorganic and Analytical Chemistry,Faculty of Pharmacy,Collegium Medicum in Bydgoszcz,Nicolaus Copernicus University in Torun,85 089,Bydgoszcz,Poland
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摘要

关键词

In vivo solid phase microextraction/Metabolite profiling/Spatial resolution/Therapeutic drug monitoring/Tissue analysis

Key words

In vivo solid phase microextraction/Metabolite profiling/Spatial resolution/Therapeutic drug monitoring/Tissue analysis

引用本文复制引用

Barbara Bojko,German Gómez-Ríos,Marcos Tascon,Krzysztof Goryński,Marcelo Cypel,Janusz Pawliszyn,Nikita Looby,Mariola Olkowicz,Anna Roszkowska,Bogumiła Kupcewicz,Pedro Reck dos Santos,Khaled Ramadan,Shaf Keshavjee,Thomas K.Waddell..Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion[J].药物分析学报（英文）,2021,11(1):37-47,11.

基金项目

We are grateful to the Canadian Cancer Society for its support in the development of IVLP via innovation grants,as well as its further support in the clinical trial with DOX IVLP as part of the innovation-to-impact grant.We are also grateful to the Canadian Institute of Health Research(CIHR)-Natural Sciences and Engineering Research Council(NSERC)of Canada Collaborative Health Research Projects program for the financial support(Grant No.355935 entitled"Supervised in vivo lung perfusion strategy for treatment of cancer metastases to the lungs.Real-time monitoring of chemotherapy by on-site analytical platform")and the Natural Sciences and Engineering Research Council of Canada Industrial Research Chair(IRC)program.We would like to thank our collaborators at Millipore/Sigma for kindly providing us with the fibers and chromatographic columns employed for this investigation.We would also like to thank Thermo Fisher Scientific for lending us the triple quadrupole mass spectrometer that was used in this work(TSQ Quantiva). （CIHR）

药物分析学报（英文）

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ISSN：2095-1779

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