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Evaluation of the combined activity of benzimidazole arylhydrazones as new anti-Parkinsonian agents: monoamine oxidase-B inhibition, neuroprotection and oxidative stress modulation

Neda Anastassova Virginia Tzankova Denitsa Yancheva Denitsa Aluani Anton Kostadinov Miroslav Rangelov Nadezhda Todorova Nadya Hristova-Avakumova Maria Argirova Nikolay Lumov Magdalena Kondeva-Burdina

中国神经再生研究（英文版）2021，Vol.16Issue(11)：2299-2309,11.

Evaluation of the combined activity of benzimidazole arylhydrazones as new anti-Parkinsonian agents: monoamine oxidase-B inhibition, neuroprotection and oxidative stress modulation

Neda Anastassova ¹Virginia Tzankova ²Denitsa Yancheva ¹Denitsa Aluani ²Anton Kostadinov ¹Miroslav Rangelov ¹Nadezhda Todorova ³Nadya Hristova-Avakumova ⁴Maria Argirova ¹Nikolay Lumov ¹Magdalena Kondeva-Burdina²

作者信息

1. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria
2. Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria
3. Institute of Biodiversity and Ecosystem Research, Bulgarian Academy ofSciences, Sofia, Bulgaria
4. Department of Medical Physics and Biophysics, Faculty of Medicine, Medical University of Sofia, Sofia, Bulgaria
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摘要

关键词

antioxidants/benzimidazoles/density functional theory/hydrazones/monoamine oxidase-B/neurodegenerative disorders/neuroprotection/oxidative stress/Parkinson's disease/synaptosomes

Key words

antioxidants/benzimidazoles/density functional theory/hydrazones/monoamine oxidase-B/neurodegenerative disorders/neuroprotection/oxidative stress/Parkinson's disease/synaptosomes

分类

医药卫生

引用本文复制引用

Neda Anastassova,Virginia Tzankova,Denitsa Yancheva,Denitsa Aluani,Anton Kostadinov,Miroslav Rangelov,Nadezhda Todorova,Nadya Hristova-Avakumova,Maria Argirova,Nikolay Lumov,Magdalena Kondeva-Burdina..Evaluation of the combined activity of benzimidazole arylhydrazones as new anti-Parkinsonian agents: monoamine oxidase-B inhibition, neuroprotection and oxidative stress modulation[J].中国神经再生研究（英文版）,2021,16(11):2299-2309,11.

基金项目

This work was supported by the National Science Fund of Bulgaria (Young scientists project contract KП-06-M29/4 （）

to NA, MA, NHA, and DA). （）

中国神经再生研究（英文版）

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ISSN：1673-5374

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