Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing
Injectable Self?Healing Adhesive pH?Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing
摘要
Abstract
ABSTRACT Endoscopic mucosal resection (EMR) and endoscopic sub-mucosal dissection (ESD) are well-established therapeutics for gastroin-testinal neoplasias, but complications after EMR/ESD, including bleeding and perforation, result in additional treatment morbidity and even threaten the lives of patients. Thus, designing biomaterials to treat gastric bleed-ing and wound healing after endoscopic treatment is highly desired and remains a challenge. Herein, a series of injectable pH-responsive self-healing adhesive hydrogels based on acryloyl-6-aminocaproic acid (AA) and AA-g-N-hydroxysuccinimide (AA-NHS) were developed, and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model. The hydrogelsshowed a suitable gelation time, an autonomous and efficient self-healing capacity, hemostatic properties, and good biocompatibility. With the introduction of AA-NHS as a micro-cross-linker, the hydrogels exhibited enhanced adhesive strength. A swine gastric hemorrhagein vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding. A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition, α-SMA expression, and blood vessel formation. These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment.关键词
Injectable self-healing hydrogel/Adhesive hydrogel/Gastric hemostasis/Gastric wound healing/Endoscopic treatmentKey words
Injectable self-healing hydrogel/Adhesive hydrogel/Gastric hemostasis/Gastric wound healing/Endoscopic treatment引用本文复制引用
Jiahui He,Gang He,Baolin Guo,Dake Chu,Zixi Zhang,Yutong Yang,Fenggang Ren,Jipeng Li,Shaojun Zhu,Feng Ma,Rongqian Wu,Yi Lv..Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing[J].纳微快报（英文）,2021,13(5):118-134,17.基金项目
This work was jointly supported by the National Natural Science Foundation of China(grant Nos.:51973172,51673155,81201927,82002957 and 81672460),the National Key Research and Development Plan of China(No.2018YFC0115300),the State Key Laboratory for Mechanical Behavior of Materials,the World-Class Universities(Disciplines)and the Characteristic Development Guidance Funds for the Cen-tral Universities,the Natural Science Foundation of Shaanxi Prov-ince(No.2020JC-03 and 2019TD-020),the Innovation Talent Pro-motion Plan of Shaanxi(No.2017KJXX-07),the Key Research and Development Program of Shaanxi Province(No.2019SF-012),and the Opening Project of Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatol-ogy,Xi'an Jiaotong University(No.2019LHM-KFKT008),and Fundamental Research Funds for the Central Universities of China(No.xjj2018090). （grant Nos.:51973172,51673155,81201927,82002957 and 81672460）
