刑事技术2021，Vol.46Issue(2)：119-126,8.DOI:10.16467/j.1008-3650.2021.0035
自主合成标准物质鉴定缴获物中的新精神活性物质ADB-FUBINACA
Identifying Seized ADB-FUBINACA of New Psychoactive Substance via Self-syn thesized Reference Standard
摘要
Abstract
New psychoactive substances (NPSs), mainly from synthetic cannabinoids, are of detrimental impact on public security worldwide. The dramatically ever-increasing NPSs cause the available reference standards unable to meet the demand with forensic identification, posing enormous challenges for forensic scientists. This article is about a successful countermeasure against the occurrence of such one challenge. Tiny amount of viscous material seized from an illicit clandestine manufacturer was analyzed through gas chromatography mass spectrometry (GC-MS), therewith having been suspected of containing synthetic cannabinoid ADB-FUBINACA, one NPS. However, the identification cannot be accomplished due to no timely available reference standard. Hence, a reference standard was synthesized of the ADB-FUBINACA in our laboratory. The synthesized chemical was essentially confirmed as the ADB-FUBINACA through GC-MS, liquid chromatograph mass spectrometer-ion trap-time of flight (LCMS-IT-TOF), nuclear magnetic resonance spectroscopy (NMR) and high performance liquid chromatography-photo-diode array (HPLC-PDA), with its purity being detected of 98.7％. Under the identical experimental conditions, both the seized material and the synthesized ADB-FUBINACA were compared through GC-MS analysis. The seized material was finally identified of harboring N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide, the ADB-FUBINACA, indeed.关键词
forensic toxicology/ADB-FUBINACA/GC-MS/LCMS-IT-TOF/NMR/reference standard synthesis/new psychoactive substance (NPS)Key words
forensic toxicology/ADB-FUBINACA/GC-MS/LCMS-IT-TOF/NMR/reference standard synthesis/new psychoactive substance (NPS)分类
社会科学引用本文复制引用
赵彦彪,郑珲,赵阳,郑晓雨,李彭,高利生..自主合成标准物质鉴定缴获物中的新精神活性物质ADB-FUBINACA[J].刑事技术,2021,46(2):119-126,8.基金项目
"Thirteenth Five-year"National Key Research and Development Program of China("十三五"国家重点研发计划项目,2017YFC0803604) （"十三五"国家重点研发计划项目,2017YFC0803604）
Special Fund of Chinese Central Government for Basic Scientific Research Operations in Commonweal Research Institutes(中央级公益性科研院所基本科研业务费专项资金项目,2018JB030) （中央级公益性科研院所基本科研业务费专项资金项目,2018JB030）
