新型炭材料2021，Vol.36Issue(2)：373-389,17.DOI:10.1016/S1872-5805(21)60023-11
阳离子碳点在癌症诊断和基因治疗一体化中的研究进展
Research progress in the use of cationic carbon dots for the integration of cancer diagnosis with gene treatment
摘要
Abstract
As a type of carbon dot (CD) with a positive charge on their surface, cationic carbon dots (CCDs) can be obtained from CDs and amino-containing cationic compounds by one-step or two-step preparation. They not only retain the good fluorescence per-formance, low toxicity and biocompatibility of CDs, but also improve their gene delivery efficiency and cell uptake capacity. These excellent properties give CCDs potential advantages in the fields of the targeted fluorescence imaging of cancers and gene therapy. This paper reviews the preparation methods and properties of CCDs, suggesting that they can be used as good targeting carriers for imaging cancer and gene therapy. In addition, the basic principles of CCDs for cancer detection and treatment, and their uses in integ-rated cancer diagnosis and gene therapy are introduced. Current problems and future development trends of CCDs for this purpose are discussed.关键词
阳离子碳点/基因治疗/荧光成像/癌症诊治一体化Key words
Cationic carbon dots/Gene therapy/Fluorescent imaging/Integration of cancer diagnosis and treatment分类
医药卫生引用本文复制引用
岳林君,卫迎迎,樊江波,陈琳,李强,杜晶磊,于世平,杨永珍..阳离子碳点在癌症诊断和基因治疗一体化中的研究进展[J].新型炭材料,2021,36(2):373-389,17.基金项目
Shanxi Provincial Excellent Talents Science and Technology Innovation Project(201805D211001),National Natural Science Foundation of China(51803148),Funds for Central Government Guides Local Science and Technology Development(YDZX20201400001722),Shanxi Province Applied Basic Research Project(201901D211501,201901D211502).山西省优秀人才科技创新项目(201805D211001) （201805D211001）
国家自然科学基金项目(51803148) （51803148）
中央引导地方科技发展资金(YDZX20201400001722) （YDZX20201400001722）
山西省应用基础研究计划项目(201901D211501,201901D211502). （201901D211501,201901D211502）
