We thank Lyudmila Lukashova for micro-CT analysis,Richard D.Bell for histological images,Chikashi Terao(Kyoto University,Japan)for helpful discussions,and Dr.Hong-Hee Kim(Seoul National University,Korea)for FOS retroviral vectors.This study was supported by the Kyoto University Foundation to K.M.,the National Institute of Health(NIH)grants to L.B.I.and K-H.P-M.,and through support for the Rosensweig Genomics Center from The Tow Foundation.Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.No authors have any financial interest related to this work. （Kyoto University,Japan）