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Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis

Lijun Wang Douglas C.Moore Wentian Yang Huiliang Yang Jiahui Huang Shaopeng Pei Liyun Wang Jian Q.Feng Dian Jing Hu Zhao Henry M.Kronenberg

骨研究（英文版）2021，Vol.9Issue(1)：75-85,11.

Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis

Lijun Wang ¹Douglas C.Moore ¹Wentian Yang ¹Huiliang Yang ¹Jiahui Huang ¹Shaopeng Pei ²Liyun Wang ²Jian Q.Feng ³Dian Jing ⁴Hu Zhao ⁴Henry M.Kronenberg⁵

作者信息

1. Department of Orthopedic Surgery,Brown University Alpert Medical School and Rhode Island Hospital,Providence,RI 02903,USA
2. Department of Mechanical Engineering,University of Delaware,Newark,DE DE19716,USA
3. Department of Biomedical Sciences,Texas A&M College of Dentistry,3302 Gaston Ave,Dallas,TX 75246,USA
4. Department of Comprehensive Dentistry,Texas A&M College of Dentistry,3302 Gaston Ave,Dallas,TX 75246,USA
5. Endocrine Unit,Massachusetts General Hospital and Harvard Medical School,Boston,MA 02114,USA
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摘要

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Lijun Wang,Douglas C.Moore,Wentian Yang,Huiliang Yang,Jiahui Huang,Shaopeng Pei,Liyun Wang,Jian Q.Feng,Dian Jing,Hu Zhao,Henry M.Kronenberg..Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis[J].骨研究（英文版）,2021,9(1):75-85,11.

基金项目

We thank Dr.Thomas Clemens(Johns Hopkins University)for the Tg(Bglap-CreER)mice,Dr.Fanxin Long(Washington University)for the mycDD-Osterix expression construct,and Mr.Scott McAllister for his excellent technical support.This publication was made possible by the NIH and the National Institute of Arthritis and Musculoskeletal and Skin Diseases(NIAMS)grants RO1AR066746 and R21AR57156(W.Y.).This work was also supported by the Rhode Island Hospital Orthopedic Foundation.L.W.is a recipient of the pilot project from the National Institute for General Medicine Sciences(NIGMS)1P20 GM119943.All mouse lines,DNA constructs,and cell lines are available upon request. （Johns Hopkins University）

骨研究（英文版）

OACSCDSCI

ISSN：2095-4700

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