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Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels

Manuel A.Riquelme Sumin Gu Rui Hua Jean X.Jiang

骨研究(英文版)2021,Vol.9Issue(1):86-96,11.
骨研究(英文版)2021,Vol.9Issue(1):86-96,11.

Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels

Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels

Manuel A.Riquelme 1Sumin Gu 1Rui Hua 1Jean X.Jiang1

作者信息

  • 1. Department of Biochemistry and Structural Biology,University of Texas Health Science Center,San Antonio,TX 78229-3900,USA
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摘要

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Manuel A.Riquelme,Sumin Gu,Rui Hua,Jean X.Jiang..Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels[J].骨研究(英文版),2021,9(1):86-96,11.

基金项目

We thank Dr.Richard O.Hynes at the Massachusetts Institute of Technology for generously providing the heterozygous ITGA5(α5+/?)gene deletion and floxed ITGA5 gene(α5flx/flx)mouse strains,Dr.Sanford Shattil at the University of California at San Diego for generously providing the WOW-1 integrin antibody and Dr.Martin A.Schwartz at Yale University for generously providing GST-FNIII9-11.We thank Dr.Mark Shapiro at UTHSCSA for the technical advice and assistance and Dr.Eduardo Cardenas and Dr.Francisca Acosta at UTHSCSA for critically reading and editing the paper.This work was supported by the National Institutes of Health(NIH)grant AR072072(to J.X.J.)and the Welch Foundation grant AQ-1507(to J.X.J.).We also thank the UTHSCSA CMMI and the UTHSCSA Optical Imaging Facility supported by the Cancer Therapy and Research Center for the support provided from the NIH–National Cancer Institute P30 award CA054174 and Texas state funds. (α5+/?)

骨研究(英文版)

OACSCDSCI

2095-4700

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