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Functionality of a bicistronic construction containing HEXA and HEXB genes encoding β-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses

Alisa A.Shaimardanova Daria S.Chulpanova Valeriya V.Solovyeva Aleksandr M.Aimaletdinov Albert A.Rizvanov

中国神经再生研究（英文版）2022，Vol.17Issue(1)：122-129,8.

Functionality of a bicistronic construction containing HEXA and HEXB genes encoding β-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses

Alisa A.Shaimardanova ¹Daria S.Chulpanova ¹Valeriya V.Solovyeva ¹Aleksandr M.Aimaletdinov ¹Albert A.Rizvanov¹

作者信息

1. Institute of Fundamental Medicine and Biology,Kazan Federal University,Kazan,Russia
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摘要

关键词

bicistronic vector/cell-mediated gene therapy/GM2 gangliosidosis/P2A peptide/Sandhoff disease/Tay-Sachs disease/umbilical cord blood mononuclear cells/β-hexosaminidase

Key words

bicistronic vector/cell-mediated gene therapy/GM2 gangliosidosis/P2A peptide/Sandhoff disease/Tay-Sachs disease/umbilical cord blood mononuclear cells/β-hexosaminidase

分类

医药卫生

引用本文复制引用

Alisa A.Shaimardanova,Daria S.Chulpanova,Valeriya V.Solovyeva,Aleksandr M.Aimaletdinov,Albert A.Rizvanov..Functionality of a bicistronic construction containing HEXA and HEXB genes encoding β-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses[J].中国神经再生研究（英文版）,2022,17(1):122-129,8.

基金项目

This work was funded by the subsidy allocated to Kazan Federal University for the state assignment#0671-2020-0058 in the sphere of scientific activities. （）

中国神经再生研究（英文版）

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ISSN：1673-5374

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