动物医学进展2021，Vol.42Issue(5)：67-72,6.
沙拉沙星环糊精包合物的制备与体外释放度研究
Preparation,Characterization and in Vitro Drug Release of Sarafloxacin Inclusion Complex
摘要
Abstract
In order to prepare a new dosage form of sarafloxacin, the in vitro release of sarafloxacin was evaluated. The preparation conditions of sarafloxacin/β-cyclodextrin inclusion complex microcapsules were optimized by response surface method. The characterization experiment was carried out by scanning electron microscope (SEC). The particle size and release of cyclodextrin inclusion complex microcapsules were evaluated. The optimized parameters of response surface method were as follows: the mixture of sarafloxacin andβ-cyclodextrin was stirred at 50℃ for 4 h at 300 r/min. The particle size experiment showed that the average particle size of the inclusion complex was 1.0 μm. The in vitro release experiment showed that the cumulative dissolution of SAR/ β-CD inclusion complex reached about 97% and remained stable after 60min, the cumulative dissolution rate of physical mixture after 60min was only about 63%，and the cumulative dissolution rate of SAR powder after 60min was only about 74.4%. Sarafloxacin was successfully prepared into a new type of inclusion complex preparation，which improved the release properties of the drug and was of positive significance to the popularization of sarafloxacin.关键词
包合物/响应面法/释放度Key words
inclusion complex/response surface methodology/release分类
农业科技引用本文复制引用
姜兴粲,李冰,张继瑜..沙拉沙星环糊精包合物的制备与体外释放度研究[J].动物医学进展,2021,42(5):67-72,6.基金项目
"十二五"国家科技支撑计划项 目(2015BAD1101) （2015BAD1101）
国家现代农业产业技术体系专项(CAR-37). （CAR-37）
