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Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2

Chuan-Jun Shu Xuan Huang Hui-Hao Tang Ding-Ding Mo Jian-Wei Zhou Cheng Deng

动物学研究2021，Vol.42Issue(2)：170-181,12.
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动物学研究2021，Vol.42Issue(2)：170-181,12.DOI:10.24272/j.issn.2095-8137.2020.301

Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2

Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2

Chuan-Jun Shu 1Xuan Huang 2Hui-Hao Tang 3Ding-Ding Mo 4Jian-Wei Zhou 2Cheng Deng5

作者信息

  • 1. Department of Molecular Cell Biology&Toxicology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China
  • 2. Jiangsu Key Laboratory for Biodiversity and Biotechnology,College of Life Sciences,Nanjing Normal University,Nanjing,Jiangsu 210023,China
  • 3. Department of Bioinformatics,School of Biomedical Engineering and Informatics,Nanjing Medical University,Nanjing,Jiangsu 211166,China
  • 4. Reproductive Medical Center,Jinling Hospital Affiliated to Medical School of Nanjing University,Nanjing,Jiangsu 210002,China
  • 5. School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School,Shenzhen,Guangdong 518055,China
  • 折叠

摘要

关键词

SARS-CoV-2/COVID-19/ACE2/Spike protein/Receptor-ligand docking/Drug therapy

Key words

SARS-CoV-2/COVID-19/ACE2/Spike protein/Receptor-ligand docking/Drug therapy

引用本文复制引用

Chuan-Jun Shu,Xuan Huang,Hui-Hao Tang,Ding-Ding Mo,Jian-Wei Zhou,Cheng Deng..Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2[J].动物学研究,2021,42(2):170-181,12.

基金项目

This work was supported by the National Key Research and Development Program of China(2018YFD0900602),National Natural Science Foundation of China(31970388,31701234),Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),Natural Science Foundation of the Jiangsu Higher Education Institutions(17KJB180006),Natural Science Foundation from Jiangsu Province(BK20160043,BK20151546,15KJA180004 and BK20171035),and Jiangsu Distinguished Professor Funding （2018YFD0900602）

动物学研究

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