分析测试学报2021，Vol.40Issue(6)：805-815,11.DOI:10.3969/j.issn.1004-4957.2021.06.004
基于金属纳米簇的荧光传感平台的最新研究进展
Recent Advances in Metal Nanoclusters-based Fluorescent Platforms for Biosensing
摘要
Abstract
Biosensing platform is one of the branches of chemical sensing platform,which is sensitive to the biomole-cules and can convert the concentration changes of biomolecules into electric signal for the sensing purpose.Among the various biosensing platforms,fluorescent nano-biosensing platforms have attracted widely attention due to their advanta-ges of high sensitivity,good selectivity,operational simplicity,low cost,real-time monitoring,etc.In recent years,with the rapid development of nanotechnology,nanostructured materials(nanomaterials) exhibit some special advanta-ges in the field of biosensing.Compared with the traditional materials,nanomaterials exhibit unique physical and chemical properties,such as optical,electrical,mechanical,catalytic and magnetic properties.As a novel type of multifunctional nanomaterials in nanoscience and nanotechnology,metal(e.g.,Au,Ag,Cu,and their alloys)nanoclusters (MNCs) are typically composed of several to dozens of metal atoms whose core sizes are usually below 2 nm.Benefiting from their unique properties of strong photoluminescence,facile preparation and surface functionaliza-tion,excellent biocompatibility,ultra-small size and low toxicity,MNCs have been applied in many fields such as en-ergy catalysis,medical treatment,electronic devices and biosensing.Especially,they have extremely outstanding flu-orescent properties of large Stokes shift,tunable fluorescence emission,high optical stability and fluorescence quantum yield,compared with the traditional fluorescent organic dyes,proteins,quantum dots and other fluorescent materials.Based on the above properties,MNCs have been widely used as fluorescent nanoprobes in the field of biosensing.In this review,the latest development of MNCs based fluorescent nano-biosensing platforms on the basis of various con-struction mechanisms were presented.The applications of MNCs in the field of sensing ions,biomolecules,pH and temperature were introduced.It is believed that this review could provide some novel insights and theoretical guidance to construct more prospective biosensors based on different designed sensing mechanisms.关键词
荧光纳米探针/金属纳米簇/生物传感/纳米材料Key words
fluorescent nanoprobe/metal nanoclusters/biosensing/nanomaterial分类
化学化工引用本文复制引用
王孟珂,苏星光..基于金属纳米簇的荧光传感平台的最新研究进展[J].分析测试学报,2021,40(6):805-815,11.基金项目
National Natural Science Foundation of China(21775052,21575048) （21775052,21575048）
The Science and Technology Development project of Ji-lin province,China(20180414013GH) （20180414013GH）
