中国组织工程研究2022，Vol.26Issue(2)：276-282,7.
自噬在骨细胞中重要作用的最新研究进展:骨相关细胞活性和骨代谢
The pivotal role of autophagy in bone cells:bone-related cell activity and bone metabolism
摘要
Abstract
BACKGROUND:The importance of autophagy for maintaining cellular homeostasis and stress response has long been recognized.As a way for cells to selectively clear their damaged organelles to achieve the recycling of cellular components,autophagy has a pivotal role in bone metabolism.OBJECTIVE:To review the role and possible mechanisms of autophagy in regulating bone-related cell activity and function among bone marrow mesenchymal stem cells,osteoblasts,osteocytes,and osteoclasts.METHODS:PubMed was searched for studies related to autophagy using the keywords of "autophagy;bone marrow mesenchymal stem cells;osteoblasts;osteocytes;osteoclasts."RESULTS AND CONCLUSION:We finally included 84 papers.Autophagy plays an important role in bone metabolism.Autophagy is involved in maintaining the balance between mineralization and absorption,and then maintaining bone homeostasis.An appropriate autophagy inducer may also benefit bone remodeling.Abnormal autophagy can lead to disorders of bone balance,leading to diseases such as osteoporosis.We may prevent or treat bone-related diseases by regulating the level of autophagy as its function in maintaining the balance of mineralization and resorption in bone homeostasis.关键词
自噬/骨髓间充质干细胞/成骨细胞/骨细胞/破骨细胞/骨稳态/骨矿化/骨吸收Key words
autophagy/bone marrow mesenchymal stem cell/osteoblast/osteocyte/osteoclast/bone homeostasis/bone mineralization/bone resorption分类
医药卫生引用本文复制引用
孙友强,马超,梁萌梦,辛鹏飞,张华,向孝兵..自噬在骨细胞中重要作用的最新研究进展:骨相关细胞活性和骨代谢[J].中国组织工程研究,2022,26(2):276-282,7.基金项目
a grant from Guangdong Provincial Administration of Traditional Chinese Medicine,No.20201112(to SYQ) （to SYQ）
Youth Innovation Fund of the First Affiliated Hospital of Guangzhou University of Chinese Medicine,No.2019QN12(to SYQ)  （to SYQ）
基金资助:广东省中医药管理局项目(20201112),项目负责人:孙友强 （20201112）
广州中医药大学第一附属医院创新强院青年基金(2019QN12),项目负责人:孙友强 （2019QN12）
