东南大学学报（英文版）2021，Vol.37Issue(2)：177-183,7.DOI:10.3969/j.issn.1003-7985.2021.02.007
RNA G-四联体结构区的同义密码子进化选择
Evolutionary selection on synonymous codons in RNA G-quadruplex structural region
摘要
Abstract
To investigate how synonymous codons have been adapted to the formation of ribonucleic acid (RNA)G-quadruplex (rG4) structure,a computational searching algorithm G4Hunter was applied to detect rG4 structures in protein-coding sequences of mRNAs in five eukaryotic species.The native sequences forming rG4s were then compared with randomized sequences to evaluate selection on synonymous codons.Factors that may influence the formation of rG4 were also investigated,and the selection pressures of rG4 in different gene regions were compared to explore its potential roles in gene regulation.The results show universal selective pressure acts on synonymous codons in rG4 regions to facilitate rG4 formation in five eukaryotic organisms.While G-rich codon combinations are preferred in the rG4 structural region,C-rich codon combinations are selectively unfavorable for rG4 formation.Gene's codon usage bias,nucleotide composition,and evolutionary rate can account for the selective variations on synonymous codons among rG4 structures within a species.Moreover,rG4 structures in the translational initiation region showed significantly higher selective pressures than those in the translational elongation region.关键词
RNA结构/G-四联体/同义密码子/进化/选择Key words
ribonucleic acid (RNA) structure/G-quadruplex/synonymous codons/evolution/selection分类
生物科学引用本文复制引用
许育铭,齐婷,顾万君,陆祖宏..RNA G-四联体结构区的同义密码子进化选择[J].东南大学学报（英文版）,2021,37(2):177-183,7.基金项目
The National Key Research and Development Pro-gram of China (No.2018YFC1314900,2018YFC1314902),the Na-tional Natural Science Foundation of China (No.61571109),the Fun-damental Research Funds for the Central Universities (No.2242017K3DN04). （No.2018YFC1314900,2018YFC1314902）
