无机材料学报2021，Vol.36Issue(5)：552-560,9.DOI:10.15541/jim20200395
高强度羟基磷灰石纳米陶瓷的构建及其促成骨细胞活性研究
Construction of Hydroxyapatite Nanoceramics with High Mechanical Strength and Efficiency in Promoting the Spreading and Viability of Osteoblasts
摘要
Abstract
The present study focuses on the construction of HA nanoceramics with excellent mechanical property and osteogenic activity,and the correlation between HA precursor powders and resulting ceramics.Three precursor powders were used,i.e.HA-40 synthesized at 40℃,HA-40PEG synthesized at 40℃with PEG as a template,and HA-80 synthesized at 80℃.The results showed that grain sizes of three HA ceramics prepared by HA-40,HA-40PEG,and HA-80 precursors were(217.87±57.53),(123.22±20.16),and(316.65±68.91)nm,respectively.It demonstrated that compared with HA-40 and HA-80,HA-40PEG was more beneficial for fabricating HA nanoceramics.Among three resulting ceramics,HA-40PEG displayed the highest comprehensive strength(～300 MPa).In addition,the nano-scale HA-40PEG ceramics promoted better cell spreading and proliferation than those of submicro-scale HA-40 and HA-80 ceramics.These findings suggest that the preparation of HA precursor powders plays an important role in fabricating HA nanoceramics with simultaneous improvement of mechanical and biological properties.关键词
羟基磷灰石/纳米陶瓷/前驱粉体/致密度/细胞活力Key words
hydroxyapatite/nanoceramics/initial powder/density/cellular viability分类
化学化工引用本文复制引用
吴永豪,李向锋,朱向东,张兴栋..高强度羟基磷灰石纳米陶瓷的构建及其促成骨细胞活性研究[J].无机材料学报,2021,36(5):552-560,9.基金项目
National Key Research and Development Program of China(2016YFC1102000,2016YFC1102003) （2016YFC1102000,2016YFC1102003）
Sichuan Science and Technology Innovation Team of China(2019JDTD0008). （2019JDTD0008）
