Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis TherapyOACSCD
Nanoparticle–Cartilage Interaction: Pathology?Based Intra?articular Drug Delivery for Osteoarthritis Therapy
Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge medical and socioeconomic burdens. Intra-articular administration of agents is clinically used for pain management. However, the effectiveness is inapparent caused by the rapid clearance of agents. To overcome this issue, nanoparticles as delivery systems hold considerable promise for local control of the pharmacokinetics of therapeuticagents. Given the therapeutic…查看全部>>
Xu Li;Bingyang Dai;Jiaxin Guo;Lizhen Zheng;Quanyi Guo;Jiang Peng;Jiankun Xu;Ling Qin
Musculoskeletal Research Laboratory,Department of Orthopedics and Traumatology,The Chinese University of Hong Kong,Sha Tin,Hong Kong, SAR,People's Republic of ChinaJoint Laboratory of Chinese Academic of Science and Hong Kong for Biomaterials,The Chinese University of Hong Kong,Sha Tin,Hong Kong, SAR,People's Republic of ChinaInnovative Orthopedic Biomaterial and Drug Translational Research Laboratory,Li Ka Shing Institute of Health Sciences,The Chinese University of Hong Kong,Sha Tin,Hong Kong, SAR,People's Republic of ChinaMusculoskeletal Research Laboratory,Department of Orthopedics and Traumatology,The Chinese University of Hong Kong,Sha Tin,Hong Kong, SAR,People's Republic of ChinaJoint Laboratory of Chinese Academic of Science and Hong Kong for Biomaterials,The Chinese University of Hong Kong,Sha Tin,Hong Kong, SAR,People's Republic of ChinaInnovative Orthopedic Biomaterial and Drug Translational Research Laboratory,Li Ka Shing Institute of Health Sciences,The Chinese University of Hong Kong,Sha Tin,Hong Kong, SAR,People's Republic of ChinaMusculoskeletal Research Laboratory,Department of Orthopedics and Traumatology,The Chinese University of Hong Kong,Sha Tin,Hong Kong, SAR,People's Republic of ChinaJoint Laboratory of Chinese Academic of Science and Hong Kong for Biomaterials,The Chinese University of Hong Kong,Sha Tin,Hong Kong, SAR,People's Republic of China
NanoparticleDrug deliveryOsteoarthritisArticular cartilageNanomedicine
NanoparticleDrug deliveryOsteoarthritisArticular cartilageNanomedicine
《纳微快报（英文）》 2021 (10)
29-76,48
The work was supported by RGC Themebased Research Scheme of Hong Kong(T13-402/17N),National Natural Science Foundation of China(81802152),Natural Science Foundation of Guangdong Province(2019A1515012224),RGC Areas of Excellence(AoE/M-402/20),RGC Collaborative Research Fund(C4026-17WF),General Research Fund(14121918 and 14173917),the Innovation and Technology Commission Funding(ITS/208/18FX),and Key-Area Research and Development Program of Guangdong Province(2019B010941001).
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