纳微快报（英文）2021，Vol.13Issue(10)：29-76,48.
Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy
Nanoparticle–Cartilage Interaction: Pathology?Based Intra?articular Drug Delivery for Osteoarthritis Therapy
摘要
Abstract
Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge medical and socioeconomic burdens. Intra-articular administration of agents is clinically used for pain management. However, the effectiveness is inapparent caused by the rapid clearance of agents. To overcome this issue, nanoparticles as delivery systems hold considerable promise for local control of the pharmacokinetics of therapeuticagents. Given the therapeutic programs are inseparable from pathological progress of osteoarthritis, an ideal delivery system should allow the release of therapeutic agents upon specific features of disorders. In this review, we firstly introduce the pathological features of osteoarthritis and the design concept for accurate localization within cartilage for sustained drug release. Then, we review the interactions of nanoparticles with cartilage microenvironment and the rational design. Furthermore, we highlight advances in the therapeutic schemes according to the pathology signals. Finally, armed with an updated understanding of the pathological mechanisms, we place an emphasis on the development of "smart" bioresponsive and multiple modality nanoparticles on the near horizon to interact with the pathological signals. We anticipate that the exploration of nanoparticles by balancing the efficacy, safety, and complexity will lay down a solid foundation tangible for clinical translation.关键词
Nanoparticle/Drug delivery/Osteoarthritis/Articular cartilage/NanomedicineKey words
Nanoparticle/Drug delivery/Osteoarthritis/Articular cartilage/Nanomedicine引用本文复制引用
Xu Li,Bingyang Dai,Jiaxin Guo,Lizhen Zheng,Quanyi Guo,Jiang Peng,Jiankun Xu,Ling Qin..Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy[J].纳微快报（英文）,2021,13(10):29-76,48.基金项目
The work was supported by RGC Themebased Research Scheme of Hong Kong(T13-402/17N),National Natural Science Foundation of China(81802152),Natural Science Foundation of Guangdong Province(2019A1515012224),RGC Areas of Excellence(AoE/M-402/20),RGC Collaborative Research Fund(C4026-17WF),General Research Fund(14121918 and 14173917),the Innovation and Technology Commission Funding(ITS/208/18FX),and Key-Area Research and Development Program of Guangdong Province(2019B010941001). （T13-402/17N）
