皮肤性病诊疗学杂志2021，Vol.28Issue(4)：245-253,9.DOI:10.3969/j.issn.1674-8468.2021.04.001
原发性干燥综合征患者伴发中枢神经病变的相关风险因子分析
Analysis of risk factors associated with central neuropathy in patients with primary Sj?gren′s syndrome
摘要
Abstract
Objective:To explore the clinical manifestations and risk factors of primary Sj?gren′s syndrome associated central nervous system(pSS-CNS).Methods:A total of 291 patients with primary Sj?gren′s syndrome(pSS)in Nanfang Hospital of Southern Medical University from January 2015 to De-cember 2020 were selected and divided into the pSS-CNS group and pSS-non-CNS group.The general conditions,laboratory data were collected to analyze the clinical characteristics between the two groups. Then multivariate Logistic regression analysis was performed on the risk factors of pSS-CNS,and ROC curve was drawn to evaluate the predictive value of each risk factor.Results:①pSS-CNS patients were mainly neuromyelitis optic spectrum disorders (NMOSD,15 cases,33. 3％),the other 30 cases includ-ed leukoaraiosis,stroke,epilepsy,dementia and other central lesions.② pSS-CNS group had a higher European League Against Rheumatism Sj?gren′s Syndrome Disease Activity Index (ESSDAI)than pSS-nCNS group [(11 . 14 ±2. 97 )vs (5. 39 ±2. 06 ),P<0. 01 ].③The independent risk factors for pSS-CNS were IgG (OR:0. 890;95％CI:0. 826～0. 959;P=0. 002),IgM(OR:0. 367;95％CI:0. 182～0. 739;P=0. 005 ),CH50 (OR:0. 935;95％ CI:0. 901 ～0. 970;P<0. 01 ),PLT (OR:1 . 005;95％CI:1 . 001 ～1 . 009;P=0. 010),the following curves of the four area:0. 890(0. 826～0. 959),0. 367 (0. 182～0. 739),0. 935(0. 901 ～0. 970),1 . 005(1 . 001 ～1 . 009),and the area under the curve of the combined application of the four was 0. 790 (0. 761 ～0. 858).Conclusions:The clinical manifesta-tions of pSS-CNS are varied.Some patients may present the symptoms of central nervous system as their first or only clinical symptom.In our study,NMOSD was the most common one.IgG,IgM,CH50 and PLT are independent risk factors for pSS-CNS,among which,the higher the PLT,the lower the IgG, IgM and CH50,and the higher the possibility of central neuropathy.关键词
原发性干燥综合征/中枢神经系统损害/视神经脊髓炎谱系/危险因素分析Key words
primary Sjögren′s syndrome/central nervous system/neuromyelitis optic spectrum disorders/risk factors analysis引用本文复制引用
袁超,郑佳曼,郑丽娟,梁人戈,刘嘉怡,黄琴..原发性干燥综合征患者伴发中枢神经病变的相关风险因子分析[J].皮肤性病诊疗学杂志,2021,28(4):245-253,9.基金项目
Supported by National Natural Science Foundation of China(No.82001315),and the Science and Technology Planning Project of Guangzhou(No.202102020832). （No.82001315）
