国际眼科杂志2021，Vol.21Issue(9)：1499-1503,5.DOI:10.3980/j.issn.1672-5123.2021.9.01
不同联合手术治疗伴有和不伴有玻璃体积血的新生血管性青光眼
Different surgical combinations for neovascular glaucoma with and without vitreous hemorrhage
摘要
Abstract
AIM: To investigate the effect of conbercept intravitreal injection combined with glaucoma drainage device implantation and panretinal photocoagulation for neovascular glaucoma ( NVG ) with and without vitreous hemorrhage.·METHODS: In this retrospective study, 39 eyes in 37 patients who were diagnosed with NVG with and without vitreous hemorrhage ( where iridotrabecular contact is more than 180° ) in the ophthalmology department of Xi' an No.1 Hospital between January 2016 and December 2017 were enrolled in this study. Patients were divided into two groups, based on whether they had vitreous hemorrhage. All patients received 0. 5 mg ( 0. 05 Ml ) conbercept intravitreal injection. Twenty-one eyes in 20 patiants ( Group 1) without vitreous hemorrhage received EX-PRESS ( P50) glaucoma drainage device implantation on 4d after conbercept intravitreal injection and then received panretinal photocoagulation 2wk after implantation. Eighteen eyes in 17 patients ( Group 2) with vitreous hemorrhage received vitrectomy combined with the EX - PRESS ( P50 ) glaucoma drainage device implantation and panretinal photocoagulation on 4d after conbercept intravitreal injection. Air or silicone oil was selectively filled according to the situation during the operation. All patients were followed up for 6mo after operation.·RESULTS: No statistical difference was found between preoperative best corrected visual acuity ( BCVA ) and postoperative (6mo) BCVA in Group 1 (P>0.05). There was statistical difference between preoperative BCVA and postoperative ( 6mo ) BCVA in Group 2 ( P<0. 05 ) . The intraocular pressure ( IOP ) of Group 1 at postoperative 1d, 1wk, 1, 3 and 6mo was 20.5 ± 4. 3 mmHg, 19. 6 ± 3.8 mmHg, 20.1 ± 3. 7 mmHg, 19. 9 ± 4.2 mmHg, and 19. 3 ± 2.9 mmHg, respectively. The postoperative IOP of Group 2 was 22.3 ± 3. 7 mmHg, 20. 6 ± 2.8 mmHg, 20. 4 ± 3. 8 mmHg, 18.9± 4. 1 mmHg, and 19. 3 ± 3. 4 mmHg, respectively. The postoperative IOP of every time point was significantly lower than the preoperative IOP in Group 1 and Group 2 ( P< 0. 05 ) . During the follow up, three eyes in three patients showed a recurrence of iris neovascularization and were given one more 0.05 Ml conbercept intravitreal injection.· CONCLUSION: Conbercept intravitreal injection combined with glaucoma drainage device implantation and panretinal photocoagulation can effectively reduce IOP in NVG ( where the iridotrabecular touch is more than 180° ) .关键词
新生血管性青光眼/康柏西普/青光眼引流器植入术/玻璃体切除术/全视网膜激光光凝术Key words
neovascular glaucoma/Conbercept/glaucoma drainage device implantation/vitrectomy/panretinal photocoagulation引用本文复制引用
黄磊,陈承,王彤,储昭节,陈晓冬..不同联合手术治疗伴有和不伴有玻璃体积血的新生血管性青光眼[J].国际眼科杂志,2021,21(9):1499-1503,5.基金项目
Shaanxi Province Social Development and Technology Research Project(No.2020SF-272) （No.2020SF-272）
Health Scientific Research and Talents Project of Xi'an City Health Commission in China(No.J201902040)陕西省重点研发计划一般研究项目(No.2020SF-272) （No.J201902040）
西安市卫计委卫生科研人才项目(No.J201902040) （No.J201902040）
