纳微快报（英文）2021，Vol.13Issue(11)：421-422,2.
Real Nano "Light Vaccine" Will Benefit to COVID-19 Pandemic Control
Real Nano "Light Vaccine" Will Benefit to COVID?19 Pandemic Control
摘要
Abstract
This highlight presents a recent technique of "Light Vaccine" for COVID-19 pandemic control. Though this technique has the germicidal advantage to SARS-CoV-2, its shortcomings will limit the wide and in-depth application. We make a perspective of real nano light vaccine, which will play an important role in the prevention and control of COVID-19. Briefly, This flow chart described the MWCNT was fabricated with strong acid and base conditional mixture in order to achieve the p-WCNT (chemical process); then modified with RNA layse and receptor binding domain (RBD) by covalent conjugation and physical absorption to get f-WCNT (functionalization);thereafter, f-WCNT was used in the multi-cell culture system interacting with SARS-CoV-2 to identify the special affinity of f-WCNT to ACE2 labeled alveolar type Ⅱ cells and the inhibition capacity to SARS-CoV-2. This design, is different from the so called "light vaccine", has the real function to against SARS-CoV-2 by local cellular temperature-rising through photothermal conversion under the near infrared (NIR) light irradiation, according to the physical and chemical nature of carbon nanotubes, and initiates the immune response consequently.关键词
SARS-CoV-2/COVID-19/Light/Vaccine/Photothermal conversion/NanomaterialKey words
SARS-CoV-2/COVID-19/Light/Vaccine/Photothermal conversion/Nanomaterial引用本文复制引用
Jianshe Yang..Real Nano "Light Vaccine" Will Benefit to COVID-19 Pandemic Control[J].纳微快报（英文）,2021,13(11):421-422,2.基金项目
This work was supported by National Natural Science Foundation of China(82071964),Shanghai Municipal Health Commission(GWV-10.1-XK09),and Shanghai Shenkang Center(SHDC2020CR2054B). （82071964）
