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Comparative permeability of three saikosaponins and corresponding saikogenins in Caco-2 model by a validated UHPLC-MS/MS method

Siqi Ren Jingjing Liu Yunwen Xue Mei Zhang Qiwei Liu Jie Xu Zunjian Zhang Rui Song

药物分析学报(英文)2021,Vol.11Issue(4):435-443,9.
药物分析学报(英文)2021,Vol.11Issue(4):435-443,9.

Comparative permeability of three saikosaponins and corresponding saikogenins in Caco-2 model by a validated UHPLC-MS/MS method

Comparative permeability of three saikosaponins and corresponding saikogenins in Caco-2 model by a validated UHPLC-MS/MS method

Siqi Ren 1Jingjing Liu 2Yunwen Xue 1Mei Zhang 2Qiwei Liu 1Jie Xu 2Zunjian Zhang 1Rui Song2

作者信息

  • 1. Key Laboratory of Drug Quality Control and Pharmacovigilance,China Pharmaceutical University,Nanjing,210009,China
  • 2. State Key Laboratory of Natural Medicine,China Pharmaceutical University,Nanjing,210009,China
  • 折叠

摘要

关键词

Bupleuri Radix/Saikosaponin/Saikogenin/UHPLC-MS/MS/Caco-2 cells/Permeability

Key words

Bupleuri Radix/Saikosaponin/Saikogenin/UHPLC-MS/MS/Caco-2 cells/Permeability

引用本文复制引用

Siqi Ren,Jingjing Liu,Yunwen Xue,Mei Zhang,Qiwei Liu,Jie Xu,Zunjian Zhang,Rui Song..Comparative permeability of three saikosaponins and corresponding saikogenins in Caco-2 model by a validated UHPLC-MS/MS method[J].药物分析学报(英文),2021,11(4):435-443,9.

基金项目

This project was financially supported by the National Natural Science Foundation of China (No.81573626),the Open Project Program of Guangxi Key Laboratory of Traditional Chinese Medi-cine Quality Standards,China (No.201503),the Natural Research Foundation of Jiangsu Province,China (No.BK20161456),and the Qing Lan Project of Jiangsu Province,China (2017).We are espe-cially grateful to Feng Xu (Center of Drug Metabolism and Phar-macokinetics,College of Pharmacy,China Pharmaceutical University,Nanjing,Jiangsu Province,China) for his help during this research. (No.81573626)

药物分析学报(英文)

OASCI

2095-1779

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