无机材料学报2021，Vol.36Issue(9)：1006-1012,7.DOI:10.15541/jim20210030
硼硅酸盐生物活性玻璃在直流电场下的体外矿化性能
In vitro Mineralization Property of Borosilicate Bioactive Glass under DC Electric Field
摘要
Abstract
Borosilicate bioactive glass has excellent bioactivity and bone conductivity, but most bioactive glasses exhibit nonlinear degradation and mineralization behavior, with mineralization property declining over time. The direct current (DC) electric field, as an outfield-assisted approach to regulation, can interfere in the ion exchange and diffusion of the glass to modify its property. In this study, a DC electric field is used to intervene in vitro mineralization of borosilicate bioactive glass to accelerate the bioactivity in the slower degradation phase. Borosilicate bioactive glass with the composition of 18SiO2-6Na2O-8K2O-8MgO-22CaO-2P2O5-36B2O3, prepared by the melting method, was immersed in simulated body fluid (SBF). A current in range of 0-90 mA was applied to study the effect of DC electric field on the degradation and in vitro mineralization property of borosilicate bioactive glass. The results show that the application of electric field increases the degradation rate and ion release of borosilicate bioactive glass. Compared to the control group (without electric field), the weight loss rate increased by 3％–5％ and the dissolution of B and Ca ions increased by 2.3–2.9 and 1.9–2.3 times, respectively. Meanwhile, the electric field assists glass network hydrolysis and surface hydroxylation, accelerating the generation of hydroxyapatite (HA). Analyzing the surface structure of the borosilicate bioactive glass particles, we found that an apatite layer was formed on the surface of the sample exposed to the electric field. Hence, the application of a DC electric field can improve the degradation and in vitro mineralization property of bioactive glass, providing a new idea for bone repair effect enhancement.关键词
硼硅酸盐生物活性玻璃/直流电场/矿化性能Key words
borosilicate bioactive glass/DC electric field/mineralization property分类
化学化工引用本文复制引用
朱子旻,张敏慧,张轩宇,姚爱华,林健,王德平..硼硅酸盐生物活性玻璃在直流电场下的体外矿化性能[J].无机材料学报,2021,36(9):1006-1012,7.基金项目
National Key Research and Development Projects(2018YFC1106300) （2018YFC1106300）
National Natural Science Foundation of China(51972232) （51972232）
