数字中医药（英文）2021，Vol.4Issue(3)：170-179,10.DOI:10.1016/j.dcmed.2021.09.002
中药处方联合核苷(酸)类似物治疗慢性乙型肝炎临床疗效及安全性Meta分析
Clinical efficacy and safety of TCM prescriptions combined with nucleoside (acid) analogues in treating chronic hepatitis B: a meta-analysis
摘要
Abstract
Objective There are many clinical reports on traditional Chinese medicine (TCM) combined with nucleoside (acid) analogues (NAs) for the treatment of chronic hepatitis B (CHB), but its effic-acy and safety are not completely clear. This meta-analysis aims to evaluate the clinical efficacy and safety thus providing evid-ence for clinical applications. Methods We searched Chinese databases the China National Knowledge Infrastructure (CNKI), Wanfang Data, and China Sci-ence and Technology Journal Database (VIP), as well as English databases PubMed and Cochrane Library, from time of establish-ment to April 14, 2021. Literature quality was evaluated accord-ing to the bias risk assessment criteria of Cochrane Collaboration network. RevMan 5.3 and Stata 12.0 software were used to per-form this research. Results A total of 23 articles, 3282 patients, and 25 TCM pre-scriptions were included in this study. NAs plus TCM remarkably improved the clinical total effective rate [Odds ratio (OR) = 3.92, P < 0.00001], TCM syndrome score (Mean difference = - 3.73, P < 0.00001), hepatitis B virus (HBV) DNA negative conversion rate (OR = 1.49, P = 0.0001), hepatitis Be antigen (HBeAg) negat-ive conversion rate (OR = 2.03, P < 0.00001), alanine aminotrans-ferase levels [Std mean difference (SMD) = - 0.95, P < 0.00001], and aspartate aminotransferase levels (SMD = - 0.70, P = 0.0004). Adverse reaction rates did not increase in the combined treat-ment group (OR = 0.97, P = 0.84). A comprehensive analysis of the 25 TCM prescriptions suggested that the combination of spleen-strengthening prescriptions with NAs showed better effects than other prescriptions.Conclusion TCM in combination with NAs, demonstrated better clinical efficacy against CHB than NAs alone. In addition, the combination of spleen-strengthening prescriptions and NAs was identified as the best therapeutic strategy. However, more ran-domized controlled trials of high quality are needed to provide more reliable clinical basis for the application of TCM.关键词
中药处方/健脾类方剂/核苷(酸)类似物/补充和替代医疗/慢性乙型肝炎/Meta分析Key words
Traditional Chinese medicine (TCM) prescrip-tions/Spleen-strengthening prescriptions/Nucleoside (acid) analogues (NAs)/Complementary and alternative medicine/Chronic hepatitis B (CHB)/Meta-analysis引用本文复制引用
夏宇,李鑫,满荣勇,WANG Aibing,曹建中..中药处方联合核苷(酸)类似物治疗慢性乙型肝炎临床疗效及安全性Meta分析[J].数字中医药（英文）,2021,4(3):170-179,10.基金项目
We thank for the funding support from the Hundred Talents Program of Hunan Province(No.9999004007),and the Startup grant of Hunan Uni-versity of Chinese Medicine(No.999900201107). （No.9999004007）
