烟台大学学报（自然科学与工程版）2021，Vol.34Issue(4)：436-441,6.DOI:10.13951/j.cnki.37-1213/n.201102
新型喜树碱衍生物PCC0208021的合成及其体外抗人结直肠癌细胞增殖作用
Synthesis and in vitro Anti-proliferation Activity against Colorectal Cancer Cells of PCC0208021 ,One Novel Camptothecin Derivatives
摘要
Abstract
A novel camptothecin derivative，designed PCC0208021 is synthesized via esterification reaction. PCC0208021 inhibits the proliferation in vitro against 4 colorectal cancer cell lines (LS180，HCT116，HT-29 and CT-26 )，and inhibits the colony formation in vitro against 2 colorectal cancer cell lines (LS180 and HCT116). Also, it can suppress the activity of Topo I and display a high binding affinity in the molecular docking study，and thus is expected to become a lead compound for the treatment of colorectal cancer.关键词
新型喜树碱衍生物/结直肠癌/体外抗肿瘤活性/TopoⅠ抑制剂Key words
novel camptothecin derivative/nolorectal cancer/ anti-proliferation/Topo I分类
医药卫生引用本文复制引用
李敏,魏颖杰,刘宗亮,邹方霞,王洪波,田京伟..新型喜树碱衍生物PCC0208021的合成及其体外抗人结直肠癌细胞增殖作用[J].烟台大学学报（自然科学与工程版）,2021,34(4):436-441,6.基金项目
国家自然科学基金资助项目NSFC(82073888) （82073888）
山东省高等学校优秀青年创新团队资助项目(2019KJM009). （2019KJM009）
