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Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4

Yao Fan Motoki Egi Fangjia Li Kazumasa Minami Amanda P.Siegel Takashi Horiuchi Jing Liu Mangilal Agarwal Akihiro Sudo Harikrishna Nakshatri Bai-Yan Li Rongrong Zha Hiroki Yokota Tomohiko Sano Xinyu Zhao Shengzhi Liu Mark D.Woollam Di Wu Xun Sun Kexin Li

骨研究（英文版）2021，Vol.9Issue(3)：313-322,10.

Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4

Yao Fan ¹Motoki Egi ²Fangjia Li ²Kazumasa Minami ³Amanda P.Siegel ⁴Takashi Horiuchi ⁵Jing Liu ⁶Mangilal Agarwal ⁷Akihiro Sudo ³Harikrishna Nakshatri ⁴Bai-Yan Li ⁸Rongrong Zha ⁷Hiroki Yokota ⁹Tomohiko Sano ⁸Xinyu Zhao ¹⁰Shengzhi Liu ¹Mark D.Woollam ¹Di Wu ²Xun Sun ¹Kexin Li²

作者信息

1. Department of Phamacology,School of Pharmacy,Harbin Medical University,Harbin,China
2. Department of Biomedical Engineering,Indiana University Purdue University Indianapolis,Indianapolis,Indiana,USA
3. Graduate School of Engineering,Mie University,Mie,Japan
4. Department of Physics,Indiana University Purdue University Indianapolis,Indianapolis,IN,USA
5. Department of Radiation Oncology,Osaka University Graduate School of Medicine,Suita,Osaka,Japan
6. Department of Chemistry and Chemical Biology,Indiana University Purdue University Indianapolis,Indianapolis,IN,USA
7. Integrative Nanosystems Development Institute,Indiana University Purdue University Indianapolis,Indianapolis,IN,USA
8. Simon Cancer Center,Indiana University School of Medicine,Indianapolis,IN,USA
9. Department of Orthopedic Surgery,Mie University,Mie,Japan
10. Department of Surgery,Simon Cancer Research Center,Indiana University School of Medicine,Indianapolis,IN,USA
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摘要

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Yao Fan,Motoki Egi,Fangjia Li,Kazumasa Minami,Amanda P.Siegel,Takashi Horiuchi,Jing Liu,Mangilal Agarwal,Akihiro Sudo,Harikrishna Nakshatri,Bai-Yan Li,Rongrong Zha,Hiroki Yokota,Tomohiko Sano,Xinyu Zhao,Shengzhi Liu,Mark D.Woollam,Di Wu,Xun Sun,Kexin Li..Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4[J].骨研究（英文版）,2021,9(3):313-322,10.

基金项目

The authors thank Stanley Chien for electrostimulation,Rahul Prakash for FRET data analysis,and Chuanpeng Dong and Yunlong Liu for bioinformatics analysis.This study was supported in part by funds from the NIH(R01 AR052144 and R03 CA238555 to H.Y.). （R01 AR052144 and R03 CA238555 to H.Y.）

骨研究（英文版）

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ISSN：2095-4700

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