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Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs

Yibo Gan Yangli Xie Min Jin Shuo Huang Bing Liu Peng Liu Jian He Jun Zhu Zhengyang Xu Zhong Wang Jing Yan Ou Hu Zhijie Bai Lin Chen

骨研究（英文版）2021，Vol.9Issue(3)：410-424,15.

Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs

Yibo Gan ¹Yangli Xie ²Min Jin ³Shuo Huang ³Bing Liu ³Peng Liu ⁴Jian He ⁵Jun Zhu ⁶Zhengyang Xu ¹Zhong Wang ²Jing Yan ⁴Ou Hu ¹Zhijie Bai ⁴Lin Chen¹

作者信息

1. Department of Spine Surgery,Center of Orthopedics,Daping Hospital,Army Medical University(Third Military Medical University),Chongqing,China
2. State Key Laboratory of Trauma,Burns and Combined Injury,Army Medical University(Third Military Medical University),Chongqing,China
3. Center of Bone Metabolism and Repair,State Key Laboratory of Trauma,Burns and Combined Injury,Trauma Center,Research Institute of Surgery,Laboratory for the Prevention and Rehabilitation of Military Training Related Injuries,Daping Hospital,Army Medical University(Third Military Medical University),Chongqing,China
4. State Key Laboratory of Proteomics,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing,China
5. State Key Laboratory of Experimental Hematology,Institute of Hematology,Fifth Medical Center of Chinese PLA General Hospital,Beijing,China
6. Key Laboratory for Regenerative Medicine of Ministry of Education,Institute of Hematology,School of Medicine,Jinan University,Guangzhou,China
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摘要

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Yibo Gan,Yangli Xie,Min Jin,Shuo Huang,Bing Liu,Peng Liu,Jian He,Jun Zhu,Zhengyang Xu,Zhong Wang,Jing Yan,Ou Hu,Zhijie Bai,Lin Chen..Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs[J].骨研究（英文版）,2021,9(3):410-424,15.

基金项目

The authors thank Hongxia Hu and Haitao Hu from Berry Genomics for technical support with scRNA-seq.The authors acknowledge Zhigang Zhou and Feng Wei from Peking University Third Hospital and Fei Luo,Bo Yu,Bo Huang,Qizhao Huang,Qinghua Ma,and Ruili Cai from Army Medical University for their excellent technical support with sample collection and single-cell preparation.The authors are grateful to Wenxia Zheng and Hengsheng Tao from Olympus and Xue Yang and Qing Zhou from Army Medical University for help with section staining and imaging.This study was supported by grants from the National Natural Science Foundation of China(81802165 and 31930054),National Key Research and Development Program of China(2017YFA0103401 and 2019YFA0110201),Training Plan of Talents'Innovation of Army Medical Center of PLA(2019CXJSB013),Postdoctoral Innovative Talent Support Program in Chongqing(2019-298),and Fund for Excellent Young Scholars of the State Key Laboratory of Trauma,Burns and Combined Injury(SKLYQ201902). （81802165 and 31930054）

骨研究（英文版）

OACSCDSCI

ISSN：2095-4700

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