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Macrophage exosomes transfer angiotensin Ⅱ type 1 receptor to lung fibroblasts mediating bleomycin-induced pulmonary fibrosis

Na-Na Sun Yue Zhang Wen-Hui Huang Bo-Jun Zheng Si-Yi Jin Xu Li Ying Meng

中华医学杂志（英文版）2021，Vol.134Issue(18)：2175-2185,11.

中华医学杂志（英文版）2021，Vol.134Issue(18)：2175-2185,11.DOI:10.1097/CM9.0000000000001605

Macrophage exosomes transfer angiotensin Ⅱ type 1 receptor to lung fibroblasts mediating bleomycin-induced pulmonary fibrosis

Na-Na Sun ¹Yue Zhang ²Wen-Hui Huang ¹Bo-Jun Zheng ¹Si-Yi Jin ¹Xu Li ³Ying Meng⁴

作者信息

1. Departments of Respiratory and Critical Care Medicine,Chronic Airways Diseases Laboratory,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China
2. Department of Respiratory Diseases,Southern Medical University Xiaolan Affiliated Hospital,Zhongshan Xiaolan Renmin Hospital,Zhongshan,Guangdong 528415,China
3. Department of Critical Care Medicine,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510006,China
4. Department of Emergency,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China
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摘要

关键词

Angiotensin-converting enzyme (ACE)/angiotensin Ⅱ (Ang Ⅱ)/angiotensin Ⅱ type 1 receptor (AT1R) axis/Exosomes/Idiopathic pulmonary fibrosis/Lung fibroblasts/Macrophages

Key words

Angiotensin-converting enzyme (ACE)/angiotensin Ⅱ (Ang Ⅱ)/angiotensin Ⅱ type 1 receptor (AT1R) axis/Exosomes/Idiopathic pulmonary fibrosis/Lung fibroblasts/Macrophages

引用本文复制引用

Na-Na Sun,Yue Zhang,Wen-Hui Huang,Bo-Jun Zheng,Si-Yi Jin,Xu Li,Ying Meng..Macrophage exosomes transfer angiotensin Ⅱ type 1 receptor to lung fibroblasts mediating bleomycin-induced pulmonary fibrosis[J].中华医学杂志（英文版）,2021,134(18):2175-2185,11.

基金项目

This study was supported by the Science and Technology Project in Guangzhou (No.201904010482) and the National Natural Science Foundation of China (Nos.81570064,81870068,and 82070063). （No.201904010482）

中华医学杂志（英文版）

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ISSN：0366-6999

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