山西大学学报（自然科学版）2021，Vol.44Issue(4)：788-797,10.DOI:10.13451/j.sxu.ns.2021033
双臂夹结构的高效抗菌剂及其治疗伤口感染研究
An Effective Antibacterial Agent with Double Arm Clamp Configuration for Treatment of Wound Infections
摘要
Abstract
Pathogenic bacteria are always one of threat to human health. Developing novel and effective bactericides to replace cur-rent antibiotics is significant and imperative. We designed and synthesized a pyridine quaternary ammonium salt with double arm clamp configuration as an antibacterial material. By taking advantage of the bridging role and electron donating action of 2, 2'-bis(4-(bromomethyl)benzyloxy)-1, 1'-dinaphthalene, two pyridine molecules can join together to obtain increased positive charges and an-tibacterial activity. The synthesized antibacterial material can effectively kill three common pathogenic bacteria including Escherich-ia coli (ampicillin-resistant), Pseudomonas aeruginosa, and Salmonella typhimurium at a low concentration. The mechanism of membrane-disrupted is proved to be related to the interaction with lipopolysaccharide. Furthermore, it is successfully applied to the treatment of bacteria-infected wound of living mice without obvious biotoxicity.关键词
抗菌剂/破膜机制/吡啶季铵盐/伤口感染Key words
antibacterial agent/membrane-disrupted mechanism/pyridine quaternary ammonium salt/wound infection分类
化学化工引用本文复制引用
王晓菊,李颖,周思荣,冯丽恒..双臂夹结构的高效抗菌剂及其治疗伤口感染研究[J].山西大学学报（自然科学版）,2021,44(4):788-797,10.基金项目
国家自然科学基金(21977065 （）
21807067 （）
21601111) （）
"三晋学者"特聘教授支持计划(2017-06) （2017-06）
