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首页|期刊导航|药物分析学报(英文)|Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

Zheng-Wei Zhang Jian-Dong Jiang Lin Cong Ran Peng Pei Han Shu-Rong Ma Li-Bin Pan Jie Fu Hang Yu Yan Wang

药物分析学报(英文)2021,Vol.11Issue(5):628-637,10.
药物分析学报(英文)2021,Vol.11Issue(5):628-637,10.

Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

Zheng-Wei Zhang 1Jian-Dong Jiang 1Lin Cong 1Ran Peng 1Pei Han 1Shu-Rong Ma 1Li-Bin Pan 1Jie Fu 1Hang Yu 1Yan Wang1

作者信息

  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,100050,China
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摘要

关键词

Berberine/Biotransformation/Gut microbiota/CYP51/Demethylated metabolite

Key words

Berberine/Biotransformation/Gut microbiota/CYP51/Demethylated metabolite

引用本文复制引用

Zheng-Wei Zhang,Jian-Dong Jiang,Lin Cong,Ran Peng,Pei Han,Shu-Rong Ma,Li-Bin Pan,Jie Fu,Hang Yu,Yan Wang..Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota[J].药物分析学报(英文),2021,11(5):628-637,10.

基金项目

The project was supported by CAMS Innovation Fund for Med-ical Sciences(CIFMS,Grant No.:2016-I2M-3-011,China),the Na-tional Natural Science Foundation of China(Grant Nos.:81803613 and 81973290),Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study(Grant No.:Z141102004414062,China),Beijing Natural Sciences Fund Key Projects(Grant No.:7181007)and the National Megaproject for Innovative Drugs(Grant No.:2018ZX09711001-002-002).We would like to thank Shimadzu(China)Co.,Ltd.for technological support. (CIFMS,Grant No.:2016-I2M-3-011,China)

药物分析学报(英文)

OASCI

2095-1779

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