国际眼科杂志2021，Vol.21Issue(12)：2026-2031,6.DOI:10.3980/j.issn.1672-5123.2021.12.02
玻璃体腔注射雷珠单抗联合全视网膜光凝术后行小梁切除术治疗新生血管性青光眼
Preoperative intravitreal Ranibizumab with panretinal photocoagulation trabeculectomy without drainage device for neovascular glaucoma
韩晓冬 1孟(王乐) 1陈小瑾 2严展军 2宋科伟2
作者信息
- 1. 710014 中国陕西省西安市,西安爱尔古城眼科医院
- 2. 712000 中国陕西省咸阳市,咸阳爱尔眼科医院
- 折叠
摘要
Abstract
?AIM:To evaluate the efficacy and safety of preoperative intravitreal injection of ranibizumab ( IVR) and panretinal photocoagulation ( PRP ) combined with conventional trabeculectomy without drainage device in patients with neovascular glaucoma ( NVG) .?METHODS: The charts of 27 patients ( 27 eyes ) who presented with NVG in our hospital between August 2015 and November 2018 were reviewed. All eyes were treated using the standard protocol of IVR accompanied by PRP, followed by conventional trabeculectomy without drainage device. The main outcomes were intraocular pressure ( IOP) control, change in best-corrected visual acuity ( BCVA) , and surgical complications.?RESULTS: The postoperative follow-up periods for all patients were at least 18 ( mean 21. 7 ± 4. 3 ) mo. The IOP significantly decreased from 45. 7 ± 5. 1 mmHg ( baseline ) to 18.4±3.6 mmHg (last visit), and BCVA (LogMAR) improved from 2.42±0.68 (baseline) to 1.77±0.93 (last visit). The success rate was higher in eyes with peripheral anterior synechiae ( PAS ) ≤50％ than in those with PAS > 50％ after 3mo postoperatively. The main surgical complications were hyphema ( 11. 1％) and hypotony with a shallow anterior chamber (14.8％) during the early postoperative stage, along with encapsulated bleb (37.0％) during the mid - late postoperative stage. Serious intraoperative or postoperative complications were not observed.? CONCLUSION: IVR and PRP combined with conventional trabeculectomy without drainage device is a safe and effective way in NVG treatment, especially for eyes with PAS≤50％. Preoperative IVR and PRP appear to improve the success rate.关键词
新生血管性青光眼/雷珠单抗/全视网膜光凝/小梁切除术Key words
neovascular glaucoma/Ranibizumab/panretinal photocoagulation/trabeculectomy引用本文复制引用
韩晓冬,孟(王乐),陈小瑾,严展军,宋科伟..玻璃体腔注射雷珠单抗联合全视网膜光凝术后行小梁切除术治疗新生血管性青光眼[J].国际眼科杂志,2021,21(12):2026-2031,6.
