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Pathogenesis and drug response of iPSC-derived cardiomyocytes from two Brugada syndrome patients with different Nav1.5-subunit mutations

Yue Zhu Minglong Chen Linlin Wang Chang Cui Huiyuan Qin Hongwu Chen Shaojie Chen Yongping Lin Hongyi Cheng Xiaohong Jiang

生物医学研究杂志（英文版）2021，Vol.35Issue(5)：395-407,13.

Pathogenesis and drug response of iPSC-derived cardiomyocytes from two Brugada syndrome patients with different Nav1.5-subunit mutations

Yue Zhu ¹Minglong Chen ¹Linlin Wang ²Chang Cui ¹Huiyuan Qin ¹Hongwu Chen ¹Shaojie Chen ¹Yongping Lin ¹Hongyi Cheng ¹Xiaohong Jiang¹

作者信息

1. Department of Cardiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China
2. Department of Cardiology,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing Chest Hospital,Nanjing,Jiangsu 210029,China
折叠

摘要

关键词

human iPSCs/Brugada syndrome/disease modeling/quinidine/SCN5A/SCN1B

Key words

human iPSCs/Brugada syndrome/disease modeling/quinidine/SCN5A/SCN1B

分类

医药卫生

引用本文复制引用

Yue Zhu,Minglong Chen,Linlin Wang,Chang Cui,Huiyuan Qin,Hongwu Chen,Shaojie Chen,Yongping Lin,Hongyi Cheng,Xiaohong Jiang..Pathogenesis and drug response of iPSC-derived cardiomyocytes from two Brugada syndrome patients with different Nav1.5-subunit mutations[J].生物医学研究杂志（英文版）,2021,35(5):395-407,13.

基金项目

The work was supported by the Natural Science Foundation of Jiangsu Province of China(Grant No.BK20160134 to LW and BK20191071 to CC),National Natural and Science Foundation of China(Grant No.81900295 to CC),and Special Foundation for Clinical Science and Technology of Jiangsu Province(Grant No.BE2017754 to HWC). （Grant No.BK20160134 to LW and BK20191071 to CC）

生物医学研究杂志（英文版）

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ISSN：1674-8301

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