摘要
Abstract
As an essential element,iron is able to assist enzymes to complete many biological activities in the body of human beings.According to Fenton chemistry,the generation of reactive oxygen species caused by iron increases the risks of cellular damage.It is therefore necessary to control the balance of the intracellular iron levels in our body. Moreover,iron is highly required in dividing cancer cells,suggesting that iron metabolism exerts significant impacts on tumour cell biology.However,the development of several useful clinical iron chelation agents such as desferriox-amine (DFO),thiosemicarbazone (5-HPCT and 3-AP)and deferiprone (DFP)has been limited in its widespread use in clinical practice because of low lipophilicity and high molecule weight.Nevertheless,some of the iron chela-tors from the hydroxypyridin-4-one (HPO)family notably,CP94 and CN128 show greater bioavailability and better physiochemistry properties,which provides a foundation of iron chelation therapy for skin cancer treatment.关键词
铁元素/铁螯合剂/氧物种/铁含量/皮肤癌/肿瘤Key words
iron/iron chelator/oxygen species/iron levels/skin cancer/tumour分类
化学化工
