数字中医药（英文）2021，Vol.4Issue(4)：251-261,11.DOI:10.1016/j.dcmed.2021.12.001
P-糖蛋白介导的中药与西药相互作用
P-glycoprotein mediated interactions between Chinese materia medica and pharmaceutical drugs
摘要
Abstract
P-glycoprotein (P-gp) is an important transmembrane ATP-bind-ing cassette (ABC) drug efflux transporter expressed in various human tissues such as the intestines, liver, kidneys, and blood-brain barrier. It limits the intracellular concentration of xenobiot-ics by pumping them out of the cells, affecting drug pharma-cokinetics and therapeutic effects. With its broad substrate spe-cificity, it has the potential to remove a wide range of drugs from Chinese materia medica (CMM), including conventional medi-cines and active compounds. Increasing evidence has confirmed the superior therapeutic effectiveness of CMM in treating a wide range of diseases worldwide, as well as in conjunction with west-ern drugs. As a result, herbal medicine-drug compounds have prompted widespread concern, with the majority of these inter-actions involving transporters such as P-gp. This review systemat-ically summarizes the inhibition or induction of P-gp expression/function by active CMM compounds and the underly-ing regulatory mechanisms. It will aid in improving understand-ing of the synergistic or inhibiting effects associated with trans-porter P-gp as well as rational safety concerns for using CMM, particularly in combination with drugs.关键词
P-糖蛋白/中药/药物相互作用/药代动力学-药效学作用/诱导剂/抑制剂Key words
P-glycoprotein (P-gp)/Chinese materia medica (CMM)/Drug interactions/Pharmacokinetic-pharmacodynamic effects Inducers/Inhibitors引用本文复制引用
杨熙,彭宇中,赫宇菲,黄雪君,胥爱丽,毕晓黎,谢莹..P-糖蛋白介导的中药与西药相互作用[J].数字中医药（英文）,2021,4(4):251-261,11.基金项目
We thank for the Macau Science and Technology De-velopment Fund(No.0067/2019/A2 and No.0075/2019/AMJ)from the Macau Special Administrative Region. （No.0067/2019/A2 and No.0075/2019/AMJ）
