数字中医药（英文）2021，Vol.4Issue(4)：262-272,11.DOI:10.1016/j.dcmed.2021.12.002
类风湿关节炎实验动物模型系统综述:基础研究中可靠动物模型的选择
Systematic review of robust experimental models of rheumatoid arthritis for basic research
摘要
Abstract
Rheumatoid arthritis (RA) is a common autoimmune disease characterized by progressive joint inflammation and destruction, deformity, loss of mobility, and permanent disability. Although the cellular and molecular mechanisms involved in RA are un-derstood in detail, no drugs or therapies can completely cure RA. Many long-term efforts have been directed towards a better un-derstanding of RA pathogenesis and the development of new classes of therapeutics. Thus, the ongoing elucidation of patho-genic events underlying RA mostly relies on studies of animal models. Herein, we comprehensively review and discuss the characteristics, challenges, and unresolved of issues of various experimental models of RA to provide a basis and reference for the rational selection of experimental RA models for basic invest-igations into traditional Chinese medicine (TCM).关键词
类风湿关节炎/动物模型/病理特征/药物筛选/中医药Key words
Rheumatoid arthritis/Animal models/Pathological features/Drug screening/Traditional Chinese medicine (TCM)引用本文复制引用
林也,胡明月,张逢,戴宗顺,谢莹,蔡雄,刘良..类风湿关节炎实验动物模型系统综述:基础研究中可靠动物模型的选择[J].数字中医药（英文）,2021,4(4):262-272,11.基金项目
We thank for the funding support from the Science and Technology Innovation Program of Hunan Province(No.XKJ[2021]43-2021RC4035),and was supported by the Hunan Furong Distinguished Scholar Program(No.XJT[2020]58)and the Chinese Academy of Engineering Academician LIU Liang's Workstation of Hunan(No.XKXT[2020]34). （No.XKJ[2021]43-2021RC4035）
