数字中医药（英文）2021，Vol.4Issue(4)：273-289,17.DOI:10.1016/j.dcmed.2021.12.003
中药复方治疗功能性消化不良:一项随机、双盲、安慰剂对照试验的Meta分析
Traditional Chinese medicine compounds for the treatment of functional dyspepsia: an updated meta-analysis of randomized, double-blind, placebo-controlled trials
摘要
Abstract
Objective To evaluate the efficacy andsafety of traditional Chinese medicine (TCM) compounds for the treatment offunc-tional dyspepsia (FD). Methods The PubMed, Embase, Cochrane Library, Web of Sci-ence, Chinese Biomedical Database (CBM), Wanfang Data, China National Knowledge Infrastructure (CNKI), and China Science and Technology Journal Database (VIP) were searched to collect randomized, double-blind, and placebo-controlled trials of FD treated with TCM compounds. The search duration was from the establishment of the database to March 2, 2021. After two re-searchers independently screened the literature, extracted the data, and evaluated the bias risk included in the study, they used RevMan 5.4 software for meta-analysis. Results A total of 23 clinical trials were included, including 2898 patients. Meta-analysis showed that the overall remission rate of FD treated with TCM compounds was significantly higher than that of placebo (73.8％ vs. 46.2％) [RR = 1.50, 95％ CI (1.29, 1.76), P <0.00001]. Among the single symptoms, TCMcompounds were superior to the placebo in improving epigastric pain [MD = ﹣0.99, 95％ CI (﹣1.37,﹣0.61), P < 0.00001], epigastric burning sensa-tion [MD = ﹣0.32, 95％ CI (﹣0.59,﹣0.05), P = 0.02], postprandi-al fullness discomfort [MD =﹣1.59, 95％ CI (﹣1.96, ﹣1.21), P < 0.00001], and early satiety symptoms [MD = ﹣0.93, 95％ CI (﹣1.32, ﹣0.54), P < 0.00001]. Compared with the placebo, TCM compounds treatment can obviously improve TCM syndrome in patients with FD [MD = ﹣5.58, 95％ CI (﹣7.55,﹣3.61), P < 0.00001], gastric emptying rate [MD = 12. 22, 95％ CI (8.90, 15.55), P <0.00001], and helped to improve patients' quality of life [MD = 11.27, 95％ CI (0.10, 22.43), P = 0.05]. No severe adverse events were reported between the two groups [RR = 1.34, 95％ CI (0.91, 1.96), P =0.14]. Conclusion Our results showed that TCM compounds treatment could significantly alleviate FD symptoms, improve gastric emptying in FD patients, and help to improve their quality of life. No severe adverse reactions have been reported in clinical ap-plications. Due to the limitation of the quantity and quality of the included studies, the above conclusions need to be verified by more high-quality studies.关键词
功能性消化不良/中药复方/安慰剂/有效性/安全性Key words
Functional dyspepsia/Traditional Chinese medicine compounds/Placebo/Effectiveness/Security引用本文复制引用
罗晓颖,杨洋,毛心勇,宋耿青,刘倩,蒋天媛,魏玮..中药复方治疗功能性消化不良:一项随机、双盲、安慰剂对照试验的Meta分析[J].数字中医药（英文）,2021,4(4):273-289,17.基金项目
We thank for the funding support from the National Natural Science Foundation of China Project(No.  （）
81820108033)and the Project of Wangjing Hospital,China Academy of Chinese Medical Sciences(No.WJYY2020-18). （No.WJYY2020-18）
