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Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction

Jungho Back Hyuk-Kwon Kwon Kristin E.Yu Christopher M.Dussik Zichen Hao Michael J.Flores Yoseph Kim Izuchukwu K.Ibe Alana M.Munger Sung Wook Seo Francis Y.Lee Minh Nam Nguyen Lu Li Saelim Lee Inkyu Lee Fancheng Chen Lauren Gillinov Yeon-Ho Chung Kareme D.Alder

骨研究（英文版）2021，Vol.9Issue(4)：557-570,14.

Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction

Jungho Back ¹Hyuk-Kwon Kwon ¹Kristin E.Yu ¹Christopher M.Dussik ¹Zichen Hao ¹Michael J.Flores ²Yoseph Kim ¹Izuchukwu K.Ibe ³Alana M.Munger ¹Sung Wook Seo ¹Francis Y.Lee ⁴Minh Nam Nguyen ¹Lu Li ¹Saelim Lee ⁵Inkyu Lee ¹Fancheng Chen ⁶Lauren Gillinov ¹Yeon-Ho Chung ⁷Kareme D.Alder¹

作者信息

1. Department of Orthop?dics&Rehabilitation,Yale University,School of Medicine,New Haven,CT,USA
2. Department of Emergency&Trauma,Changhai Hospital,Navy Medical University,Shanghai,China
3. Biomedical Engineering,Johns Hopkins University,Baltimore,MD,USA
4. Department of Orthopedic Surgery,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul,Gangnam-gu,Republic of Korea
5. Research Center for Genetics and Reproductive Health,School of Medicine,Vietnam National University Ho Chi Minh City,Linh Trung Ward,Thu Duc District,Ho Chi Minh City,Vietnam
6. Department of Rehabilitation Medicine,Renji Hospital,School of Medicine,Shanghai JiaoTong University,Shanghai,China
7. College of Medicine,Dankook University,Cheonan,Republic of Korea
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摘要

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Jungho Back,Hyuk-Kwon Kwon,Kristin E.Yu,Christopher M.Dussik,Zichen Hao,Michael J.Flores,Yoseph Kim,Izuchukwu K.Ibe,Alana M.Munger,Sung Wook Seo,Francis Y.Lee,Minh Nam Nguyen,Lu Li,Saelim Lee,Inkyu Lee,Fancheng Chen,Lauren Gillinov,Yeon-Ho Chung,Kareme D.Alder..Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction[J].骨研究（英文版）,2021,9(4):557-570,14.

基金项目

The authors thank the Orthop?dic Histology and Histomorphometry Laboratory for their excellent assistance.We also thank Dr.Jong Woo Lee for critically discussing this study.This work was supported by AR056246(F.Y.L.),AR068353(F.Y.L.),and CA203011(F.Y.L.). （F.Y.L.）

骨研究（英文版）

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ISSN：2095-4700

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