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Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion

Se Hwan Mun Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun Park-Min Seyeon Bae Steven Zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim George Kalliolias Chitra Lekha Dahia

骨研究（英文版）2021，Vol.9Issue(4)：571-581,11.

Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion

Se Hwan Mun ¹Younseo Oh ²Tae-Hwan Kim ²Jong Dae Ji ³Kyung-Hyun Park-Min ⁴Seyeon Bae ¹Steven Zeng ⁵Brian Oh ⁶Carmen Chai ¹Matthew Jundong Kim ¹Haemin Kim ¹George Kalliolias ¹Chitra Lekha Dahia¹

作者信息

1. Arthritis and Tissue Degeneration Program,David Z.Rosensweig Genomics Research Center,New York,NY,USA
2. Hanyang University Institute for Rheumatology Research,Seoul,Korea
3. Department of Rheumatology,Hanyang University Hospital for Rheumatic Diseases,Seoul,Korea
4. Rheumatology,College of Medicine,Korea University,Seoul,Korea
5. BCMB allied program,Weill Cornell Graduate School of Medical Sciences,New York,NY,USA
6. Department of Medicine,Weill Cornell Medical College,New York,NY,USA
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摘要

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Se Hwan Mun,Younseo Oh,Tae-Hwan Kim,Jong Dae Ji,Kyung-Hyun Park-Min,Seyeon Bae,Steven Zeng,Brian Oh,Carmen Chai,Matthew Jundong Kim,Haemin Kim,George Kalliolias,Chitra Lekha Dahia..Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion[J].骨研究（英文版）,2021,9(4):571-581,11.

基金项目

We would like to thank Dr.Sungho Park for his helpful discussions and review of the manuscript,Drs.Miguel Otero and Lionel Ivashkiv for providing human patient samples and K/BXN serum and the HSS micro-CT core.This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases(NIAMS)of the NIH under Award Numbers R01 AR069562 and AR073156(to K.H.P.-M.).Supplementary Figure 11 was generated by Biorender. （NIAMS）

骨研究（英文版）

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ISSN：2095-4700

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