眼科学报2022，Vol.37Issue(1)：1-13,13.DOI:10.3978/j.issn.1000-4432.2022.01.03
Triton光学相干断层扫描血管成像图像中正常人的中心凹无血管区的自动测量方法
Automated foveal avascular zone measurement of Triton optical coherence tomography angiography in healthy subjects
摘要
Abstract
Background: Previous studies have proposed an automated customized program named MATLAB used in the foveal avascular zone (FAZ) measurements in Triton optical coherence tomography angiography (OCTA) images. But it is not open-source and not easy to obtain, which will largely restrict its application in clinical practice and medical research. In this study, we aimed to investigate the feasibility of the Smooth Level Sets macro (SLSM), a free and open-source program, and compared with the manual measurements and MATLAB in the FAZ quantification in Triton OCTA. Methods: Thirty-five eyes of 35 healthy subjects were scanned four times continuously using Triton OCTA. Manual and automated methods including the SLSM and MATLAB were used in the FAZ metrics (area, perimeter, and circularity) of the superficial capillary plexus. The accuracy, repeatability of all methods, and agreement between automated and manual methods were analyzed. Results: The SLSM presented higher accuracy with a higher average Dice coefficient (0.9506) than MATLAB (0.9483), which was just second to the manual method (0.9568). Both the SLSM [intraclass correlation coefficient (ICC) =0.987; coefficient of variation (CoV) =3.935％] and MATLAB (ICC =0.983; CoV =4.165％) showed excellent repeatability for the FAZ area. They also had excellent agreement with manual measurement (SLSM, ICC =0.973; MATLAB, ICC =0.968). Conclusion: The SLSM exhibits better accuracy than MATLAB in the automated FAZ measurement in Triton OCTA, the results of which were comparable to those obtained by manual measurement. This free and open-source program may be an accessible and feasible option for automated FAZ segmentation on Triton OCTA images.关键词
中心凹无血管区/光学相干断层扫描血管成像/自动测量Key words
foveal avascular zone/optical coherence tomography angiography/automated measurement引用本文复制引用
林艾迪,方丹齐,吴苇杭,容毅标,陈浩宇..Triton光学相干断层扫描血管成像图像中正常人的中心凹无血管区的自动测量方法[J].眼科学报,2022,37(1):1-13,13.基金项目
国家重点研发计划(2018YFA0701700) （2018YFA0701700）
汕头市科技计划(190917085269835).This work was supported by the National Key R&D Program(2018YFA0701700)and Shantou Science and Technology Program(190917085269835),China. （190917085269835）
