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Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

Lisa Strasser Giorgio Oliviero Craig Jakes Izabela Zaborowska Patrick Floris Meire Ribeiro da Silva Florian Füssl Sara Carillo Jonathan Bones

药物分析学报（英文）2021，Vol.11Issue(6)：726-731,6.

Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

Lisa Strasser ¹Giorgio Oliviero ¹Craig Jakes ¹Izabela Zaborowska ²Patrick Floris ¹Meire Ribeiro da Silva ¹Florian Füssl ¹Sara Carillo ¹Jonathan Bones¹

作者信息

1. Characterization and Comparability Laboratory,NIBRT-National Institute for Bioprocessing Research and Training,Dublin,A94 X099,Ireland
2. School of Chemical and Bioprocess Engineering,University College Dublin,Dublin,D04 V1W8,Ireland
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摘要

关键词

Data-independent acquisition/Host cell proteins/Critical quality attributes/Liquid chromatography-mass spectrometry/Monoclonal antibody/Chinese hamster ovary cells

Key words

Data-independent acquisition/Host cell proteins/Critical quality attributes/Liquid chromatography-mass spectrometry/Monoclonal antibody/Chinese hamster ovary cells

引用本文复制引用

Lisa Strasser,Giorgio Oliviero,Craig Jakes,Izabela Zaborowska,Patrick Floris,Meire Ribeiro da Silva,Florian Füssl,Sara Carillo,Jonathan Bones..Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS[J].药物分析学报（英文）,2021,11(6):726-731,6.

基金项目

The authors gratefully acknowledge funding from Thermo Fisher Scientific as part of a funded collaborative agreement with NIBRT. （）

药物分析学报（英文）

OASCI

ISSN：2095-1779

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