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DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer 's disease

Sha Sha Xiao-Na Xing Tao Wang Ying Li Rong-Wei Zhang Xue-Li Shen Yun-Peng Cao Le Qu

中国神经再生研究（英文版）2022，Vol.17Issue(10)：2305-2310,6.

DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer 's disease

Sha Sha ¹Xiao-Na Xing ²Tao Wang ³Ying Li ¹Rong-Wei Zhang ¹Xue-Li Shen ¹Yun-Peng Cao ⁴Le Qu⁵

作者信息

1. Department of Geriatrics,the First Affiliated Hospital of China Medical University,Shenyang,Liaoning Province,China
2. Department of Neurology,Shenzhen Luohu People's Hospital,The Third Affiliated Hospital of Shenzhen University,Shenzhen,Guangdong Province,China
3. College of Life and Health Sciences,Northeastern University,Shenyang,Liaoning Province,China
4. Department of Neurology,the First Affiliated Hospital of China Medical University,Shenyang,Liaoning Province,China
5. Department of Dermatology,the First Affiliated Hospital of China Medical University,Shenyang,Liaoning Province,China
折叠

摘要

关键词

Aβ oligomers/cognitive dysfunction/DNA vaccine/immunotherapy/neuron loss/plaque deposits/synaptic function/tau hyperphosphorylation

Key words

Aβ oligomers/cognitive dysfunction/DNA vaccine/immunotherapy/neuron loss/plaque deposits/synaptic function/tau hyperphosphorylation

引用本文复制引用

Sha Sha,Xiao-Na Xing,Tao Wang,Ying Li,Rong-Wei Zhang,Xue-Li Shen,Yun-Peng Cao,Le Qu..DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer 's disease[J].中国神经再生研究（英文版）,2022,17(10):2305-2310,6.

基金项目

This study was supported by the National Nature Science Foundation of China,No.81870819(to YPC) （to YPC）

and the Natural Science Foundation of Liaoning Province of China,No.2019-MS-200(to XNX). （to XNX）

中国神经再生研究（英文版）

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ISSN：1673-5374

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