山西大学学报（自然科学版）2022，Vol.45Issue(1)：193-199,7.DOI:10.13451/j.sxu.ns.2021010
有氧运动通过调节Lipin1 pre-mRNA选择性剪切和剪接因子SFRS10减轻体重
Aerobic Exercise Reduces Body Weight by Regulating Lipin1 Pre-mRNA Alternative Splicing and Splicing Factor SFRS10
摘要
Abstract
The effects of the aerobic exercise on mice body weight, Lipin1 pre-mRNA alternative splicing and SFRS10 by hematoxy-lin-eosin staining were evaluated by PCR and qPCR techniques. The mice body weight had a significant decrease after the aerobic exercise. The lipin1 over-expressed in obesity group was decreased after the aerobic exercise. One of isoforms, the lipin1αhad a low expression in obesity group and increased after aerobic exercise, while, the other one, the lipin1βhad the opposite change from Lipin1α. Moreover, it was found that SFRS10 was involved in the Lipin1 pre-mRNA alternative splicing induced by the aerobic ex-ercise. In a word, the aerobic exercise may lose the body weight by regulating Lipin1 level, Lipin1 pre-mRNA alternative splicing, and SFRS10.关键词
有氧运动/肥胖/减肥/Lipin1/选择性剪切/SFRS10Key words
aerobic exercise/obesity/weight loss/Lipin1/alternative splicing/SFRS10分类
社会科学引用本文复制引用
武宝爱,徐冲,杜会枝..有氧运动通过调节Lipin1 pre-mRNA选择性剪切和剪接因子SFRS10减轻体重[J].山西大学学报（自然科学版）,2022,45(1):193-199,7.基金项目
国家自然科学基金(31500962) （31500962）
