南方医科大学学报2022，Vol.42Issue(2)：163-170,8.DOI:10.12122/j.issn.1673-4254.2022.02.01
环状RNA在免疫相关疾病中的作用
Role of circular RNAs in immune-related diseases
摘要
Abstract
Objective Circular RNAs (circRNAs) are non-coding RNAs (ncRNA) circularized without a 3′polyadenylation [poly-(A)] tail or a 5′cap, resulting in a covalently closed loop structure. circRNAs were first discovered in RNA viruses in the 1970s, but only a small number of circRNAs were discovered at that time due to limitations in traditional polyadenylated transcriptome analyses. With the development of specific biochemical and computational methods, recent studies have shown the presence of abundant circRNAs in eukaryotic transcriptomes. circRNAs play vital roles in many physiological and pathological processes, such as acting as miRNA sponges, binding to RNA-binding proteins (RBPs), acting as transcriptional regulatory factors, and even serving as translation templates. Current evidence has shown that circRNAs can be potentially used as excellent biomarkers for diagnosis, therapeutic effect evaluation, and prognostic assessment of a variety of diseases, and they may also provide effective therapeutic targets due to their stability and tissue and development-stage specificity. This review focuses on the properties of circRNAs and their immune relationship to disease, and explores the role of circRNAs in immune-related diseases and the directions of future research.关键词
环状RNA/自身免疫疾病/免疫学/基因学/生物标志物Key words
circRNA/autoimmune diseases/immunology/genetics/biomarkers引用本文复制引用
詹炜杰,严涛,高嘉文,宋旻恺,王婷,林菲,周海榆,李栎,张超..环状RNA在免疫相关疾病中的作用[J].南方医科大学学报,2022,42(2):163-170,8.基金项目
国家自然科学基金(81872557) （81872557）
海南重点研发计划项目(ZDYF2021SHFZ223) Supported by National Natural Science Foundation of China and Key Research and Development Foundation of Hainan Province(No.ZDYF2021SHFZ223). （ZDYF2021SHFZ223）
