发光学报2022，Vol.43Issue(3)：430-439,10.DOI:10.37188/CJL.20210372
基于碳点的荧光探针"关-开"测定卡托普利
Sensitive Detection of Captopril Based on"Off-On" Carbon Dots as Fluorescent Probe
摘要
Abstract
Fluorescent nitrogen-doped carbon dots(NCDs) were synthesized by a facile one-step microwave strategy using lemon juice and urea. The obtained NCDs show stable blue fluorescence with a high quantum yield of 53. 1％. Hg2+can efficiently coordinate onto the surface of NCDs by means of electrostatic interactions and remarkably quench the fluo-rescence of NCDs as a result of the formation of a non-fluorescent stable NCDs-Hg2+ complex(turn-off). Static fluores-cence quenching towards Hg2+ is proved by the fluorescence lifetime measurements and the change of ultraviolet-visible ab-sorption spectra. In addition, the fluorescence of NCDs-Hg2+ system was recovered with the addition of captopril(CAP) due to the ability of captopril to coordinate with Hg2+ and the formation of strong Hg2+—S bond. When captopril was added, Hg2+ combined with captopril rather than with NCDs resulting in the remove of Hg2+ from the surface of NCDs and a significant fluorescence restore of NCDs was observed(turn-on). Under the optimized conditions, good linearity for detec-ting captopril was attained over the concentration range 0. 25-25μmol·L-1 with a detection limit of 0. 17μmol·L-1 . More-over, this NCDs-based sensor was successfully applied for quantitation of captopril in tablets with satisfactory recovery.关键词
碳点/荧光/卡托普利/Hg(Ⅱ)Key words
carbon dots/fluorescence/captopril/Hg(Ⅱ)分类
数理科学引用本文复制引用
梁倩,王玉林,郑梅琴,陈艳希,黄文杰,李光满,黄彪..基于碳点的荧光探针"关-开"测定卡托普利[J].发光学报,2022,43(3):430-439,10.基金项目
国家重点研发计划(2017YFD0601006) （2017YFD0601006）
福建省教育厅项目(kz180414,JT180846)资助 （kz180414,JT180846）
